Dr. Ehraz Anis earned his doctorate in neuroscience from Aligarh Muslin University and also his B.S. in biochemistry. His graduate work focused on mitochondrial dysfunction in rat models of Parkinson’s disease. Dr. Anis’ main lab competencies lie in animal work, molecular neurodegeneration. In 2021, he joined the laboratory of Dr. Patrik Brundin as a postdoctoral fellow.
The goal of this project is to determine the mechanisms by alpha-synuclein (α-syn) pathology in the vermiform appendix contributes to Parkinson’s. Preliminary work shows that the Parkinson’s appendix exhibits molecular signatures that are capable of facilitating the accumulation and spread of α-syn pathology. Specifically, epigenetic and transcriptional abnormalities in the PD appendix that disrupt the autophagy-lysosomal system were found, which is known to regulate α-syn levels. Truncated forms of α-syn were also found to be elevated in the PD appendix and PD appendix lysates seeded rapid α-syn aggregation. Finally, experimental data shows that α-syn aggregates from the gut are capable of reaching the brain and that this process is aggravated by intestinal inflammation. Therefore, the hypothesis is that, in PD, aberrant gene regulation in the appendix facilitates an accumulation of pathogenic α-syn, which in turn propagates to the brain to induce PD pathology.
Ph.D. in neuroscience, Aligarh Muslim University, Aligarh, India (Adviser: Dr. M. Mobarak Hossain)
Thesis: Phytomedicinal approaches Against Parkinson’s induced motor function impairment, mitochondrial toxicity and apoptosis
M.Sc. in biotechnology, Hamdard University (Jamia Hamdard), New Delhi, India
B.S. in biochemistry, Aligarh Muslim University, Aligarh, India
International Young Scientist Award In Engineering, Science and Medicine from VDGOOD Professional Association, India
To view a list of selected publications click below.
Anis E, Zafeer MF, Firdaus F, Islam SN, Khan AA, Hossain MM. 2020. Perillyl alcohol mitigates behavioural changes and limits cell death and mitochondrial changes in unilateral 6-OHDA lesion model of Parkinson’s disease through alleviation of oxidative stress. Neurotox Res 38(2):461–477.
Anis E, Zafeer MF, Firdaus F, Islam SN, Khan AA, Ali A, Hossain MM. 2020. Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6-Hydroxydopamine lesioned rats. Phytother Res 34(1):214–226.
Firdaus F, Zafeer MF, Anis E, Ahmad M, Afzal M. 2018. Ellagic acid attenuates arsenic induced neuro-inflammation and mitochondrial dysfunction associated apoptosis. Toxicol Rep 5:411–417.