Dr. Christopher Tulisiak is a postdoctoral fellow in the laboratory of Dr. Patrik Brundin at Van Andel Institute. He earned a B.A. in psychology from University of Notre Dame and an Ph.D. in neuroscience from University of Texas at Austin, where he studied in the labs of Drs. R. Adron Harris and Igor Ponomarev. While there, his work focused on the DNA-level epigenetic effects of chronic alcohol exposure on the brain. He has received numerous prestigious awards for his scholarship and research, including two Ruth L. Kirschstein National Research Service Awards from the National Institutes of Health and the F.M. Jones and H.L. Bruce Endowed Graduate Fellowship in Addiction Biology. His current work in Dr. Patrik Brundin’s laboratory centers on the effects of environmental pollutants on development and progression of Parkinson’s disease-related synucleinopathies in the brain and on repurposing of FDA-approved drugs for treatment of Parkinson’s disease pathology.
Dr. Tulisiak’s work with Dr. Patrik Brundin is centered around testing the hypothesis that exposure to nano-sized air pollutants exacerbates (or facilitates) development and progression of Parkinson’s disease-related synucleinopathies (aggregation of misfolded α-synuclein proteins) and inflammation in the brain. This project also aims to investigate the efficacy of drugs repurposed from their approved usages as anti-inflammatory or anti-diabetic agents for the amelioration of these Parkinson’s disease pathologies.
Ph.D. in neuroscience, University of Texas at Austin (Advisor: R. Adron Harris, Ph.D., and Igor Ponomarev, Ph.D.)
Thesis: Regulation of the DNA methylome in models of alcohol use disorders
B.A. in psychology, University of Notre Dame
Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship (F31AA026466), National Institutes of Health (2017–2018)
Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (T32DA018926), National Institutes of Health (2012–2014)
To view a list of selected publications click below.
Tulisiak CT, Harris RA, Ponomarev I. 2016. DNA modifications in models of alcohol use disorders. Alcohol 60:19–30.
Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Basu A, Brooks JG, Saha S, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Chetkovich DM, Vassar RJ, Byrne RW, Oh MM, Disterhoft JF, Stoub TR, Nicholson DA (2018). Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer’s disease. Neurobiol Learn Mem.
Nicholson DA, Cahill ME, Tulisiak CT, Geinisman Y, Penzes P. 2012. Spatially restricted actin-regulatory signaling contributes to synapse morphology. J Neurochem 121(6):852–860.