616.234.5000

Christian U. von Linstow, Ph.D.

Christian U. von Linstow, Ph.D.
Postdoctoral fellow, Patrik Brundin Laboratory
616.234.5853

Biography

Dr. Christian U. von Linstow is an experienced neuroscientist who earned his B.S. and M.Sc. from the University of Southern Denmark, where he investigated the mechanisms behind the differentiation of neural stem cells into transplantable dopaminergic neurons as a treatment of Parkinson’s disease. Later, Dr. von Linstow earned his Ph.D. from University of Southern Denmark under the mentorship of Professor Bente Finsen. His work focused mainly on the role of aging on the monoaminergic system during Alzheimer’s disease, how changes in the serotonergic system affects disease progression, and whether such effects involve changes in microglial behavior. Most recently, as a postdoctoral researcher, Dr. von Linstow studied the integration of neuroanatomical data with the output of machine learning algorithms applied to quantify huntingtin aggregates in Huntington’s disease. In 2019, he joined the laboratory of Dr. Patrik Brundin at Van Andel Research Institute as a postdoctoral fellow.

 

Current research focus

Dr. von Linstow’s current research addresses the role of the bHLH transcription factor Nato3 (also known as Ferd3l) on the survival of the dopaminergic (DA) neurons that progressively perish during Parkinson’s disease. Nato3 is expressed in the floor plate of the fetal brain during development of midbrain DA neurons and may act in synergy with other transcription factors such as Shh and Foxa2. Overexpressing such factors may protect fully matured DA neurons in Parkinson’s disease. This type of research is highly relevant owing to the inability of current treatment to arrest disease progression.

Education & Training

Postdoctoral researcher in Neuroinformatics, University of Oslo (Advisor: Professor Jan G. Bjaalie)

Ph.D. in neuroscience/immunology, University of Southern Denmark (Advisor: Professor Bente Finsen)
Thesis: Serotonergic modulation of amyloidosis in Alzheimer’s-like disease in mice

M.Sc. in biomedicine, University of Southern Denmark (Advisor: Assoc. Professor Morten Meyer) Thesis: Effect of novel signalling peptides on differentiation, functional capacity and survival of neural stem cells from the foetal brain

B.S. in biomedicine, University of Southern Denmark (Advisor Assoc. Professor Søren Hansen)
Thesis: Analysis of SP-D expression during acute lung injury

Awards & External Funding

Fonden af 17-12-1983 (2017)

A.J. Andersen og Hustrus Fond (2015)

Torben og Alice Frimodts Fond (2014)

Fonden til Lægevidenskabens Fremme (2014)

Faculty stipend at IMM, University of Southern Denmark (2013)

Scholar stipend at IMM, University of Southern Denmark (2012)

Publications

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Thygesen C, Ilkjær L, Kempf SJ, Hemdrup AL, von Linstow CU, Babcock AA, Darvesh S, Larsen MR, Finsen B. 2018. Diverse protein profiles in CNS myeloid cells and CNS tissue from lipopolysaccharide- and vehicle-iInjected APPSWE/PS1ΔE9 transgenic mice implicate cathepsin Z in Alzheimer’s disease. Front Cell Neurosci 12:397.

Severino M, Sivasaravanaparan M, Olesen LØ, von Linstow CU, Metaxas A, Bouzinova EV, Khan AM, Lambertsen KL, Babcock AA, Gramsbergen JB, Wiborg O, Finsen B. 2018. Established amyloid-b pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine. Alzheimers Dement (N Y) 4:215–223.

Von Linstow CU, Metaxas A, Grebing M, Waider J, Lesch KP, Finsen B. 2017. Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer’s-like disease in mice.  Alzheimers Res Ther  9:74.

Von Linstow CU, Severino M, Metaxas A, Waider J, Lesch KP, Gramsbergen JB, Finsen. 2017. Effect of aging and Alzheimer’s disease-like pathology on brain monoamines in miceNeurochemistry International 108:238–245.

Clausen BH, Lambertsen KL, Dagnæs‐Hansen F, Babcock AA, Von Linstow CU, Meldgaard M, Kristensen BW, Deierborg T, Finsen B. 2016. Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke. Acta Neuropathologica 131(5):775–791.

Grebing M, Nielsen HH, Fenger C, Jensen KT, Von Linstow CU, Clausen BH, Söderman M, Thomassen T, Kruse T, Finsen B. 2015. Myelin-specific T cells induce interleukin-1beta expression in lesion-reactive microglial-like cells in zones of axonal degeneration. GLIA 64(3):407–424.

Krabbe C, Bak ST, Jensen P, Von Linstow CU, Serrano AM, Hansen C, Meier M. 2014. Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin. PLoS One (5):e96465.

Oral/Poster Presentations

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Oral presentations 

2017. Når Hjernen Falder Fra Hinanden. Cellulære og Molekylære mekanismer ved Alzheimers sygdom, Hjerneugen (BrainWeek) supported by FENS and the DANA foundation, University of Southern Denmark 

2016. Effect of aging and AD-like pathology on brain monoamines in mice
15th Annual OAK Meeting

2014. Serotonergic modulation of amyloidosis in Alzheimer’s-like disease in mice
Translational Research Meeting on Neurological Diseases                       

2014. Serotonergic modulation of amyloidosis in Alzheimer’s-like disease in mice
Neuroseminar series, Department of Neurobiology, Institute of Molecular Medicine, SDU).

Poster presentations

2018. Whole brain analysis of Huntingtin aggregates in the F344 transgenic rat model of Huntington disease
11th FENS Forum of Neuroscience

2016. Effect of aging and Alzheimer’s-like pathology on the brain monoaminergic system
10th FENS Forum of Neuroscience

2015. Effect of aging and Alzheimer’s-like pathology on the brain monoaminergic system
Brain Prize Meeting, The Lundbeck Foundation

2015. Effect of aging and AD-like pathology on brain monoamines in mice
4th Venusberg meeting on neuroinflammation