616.234.5000

Chetan Nagaraja, Ph.D.

Chetan Nagaraja, Ph.D.
Postdoctoral fellow, Chu Laboratory
616.234.5897

Biography

Dr. Chetan Nagaraja earned his Ph.D. in neurosciences from Uppsala University and a B.S. in engineering in medical electronics from MSRIT Visveswaraya Technological University. His graduate work focused on activity patterns in interneurons and motoneurons, during fictive locomotion and other assays. After his Ph.D. studies, he was a postdoc at the National Institute of Neurological Disorders and Stroke of the National Institutes of Health, investigating if motoneuronal inputs into the central nervous system persist to adulthood. In 2020, he joined the lab of Dr. Hong-Yuan Chu as a postdoctoral fellow.

 

Current research focus

Dr. Chetan Nagaraja’s studies focus on the basic biology of Parkinson’s disease that leads to the manifestation of motor deficits and nonmotor symptoms (e.g., emotional and cognitive deficits). Dr. Nagaraja will use multidisciplinary research tools (e.g., electrophysiology, immunohistochemistry, optogenetics, chemogenetics and animal behavior analysis) to investigate molecular, cellular and circuit alterations in the cortico-basal ganglia and/or corticolimbic network in mouse models of Parkinson’s disease.

Education & Training

Postdoctorate in neurosciences, National Institutes of Health (USA)
Thesis: To characterize Ventral root evoked entrainment of disinhibited bursts across early postnatal development

Ph.D. in neurosciences, Uppsala University (Sweden)
Thesis: To characterize activity patterns in interneurons and motoneurons, during fictive locomotion and other assays

B.S. in engineering in medical electronics, MSRIT Visveswaraya Technological University (India)

Publications

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Nagaraja C. 2020. Ventral root evoked entrainment of disinhibited bursts across early postnatal development in mice. IBRO Rep 9:310–318.

Perry S*, Larhammar M*, Vieillard J, Nagaraja C, Hilscher MM, Tafreshiha A, Rofo F, Caixeta FV, Kullander K. 2019. Characterization of Dmrt3-derived neurons suggest a role within locomotor circuits. J Neurosci 39(10):1771–1782.

Enjin A*, Perry S*, Hilscher MM, Nagaraja C, Larhammar M, Gezelius H, Eriksson A, Leão KE, Kullander K. 2017. Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the renshaw cell-motor neuron circuit. J Neurosci 37(23):5634–5647.

Langer D, van’t Hoff M, Keller AJ, Nagaraja C, Pfäffli OA, Göldi M, Kasper H, Helmchen F. 2013. HelioScan: A software framework for controlling in vivo microscopy setups with high hardware flexibility, functional diversity and extendibility. J Neurosci Method 215(1):38–52.

Rogoz K, …., Nagaraja C, …., Lagerstrom MC. 2016. Identification of a neuronal receptor controlling anaphylaxis. Cell Rep 14(2):370–379.

Sharda M, Subhadra TP, Sahay S, Nagaraja C, Singh L, Mishra R, Sen A, Singhal N, Erickson D, Singh NC. 2010. Sounds of melody–pitch patterns of speech in autism. Neurosci Lett 478(1):42–45.