Meet the Postdocs

Working on an individual personalized project under the guidance of a qualified faculty mentor, VARI’s exceptional postdoctoral fellows make great contributions to the science conducted in the Institute’s laboratories. They play a crucial role in the intellectual development and management of research projects and contribute to a considerable share of the hands-on research activities in the laboratory.

VARI Fellows

DNA methylation modulation and epigenetic alterations in leukemogenesis

Center for Epigenetics

Single-cell and cell-free DNA methylation analysis in cancer

Epigenetic alterations that contribute to human disease

How chemical modifications on DNA and histone proteins influence the role of epigenetic regulatory proteins in development and cancer

Pan-cancer analysis based on dynamic epigenetic modifications

DNA methylation and the role of 5-hydroxymethylcytosine in cancer

Epigenetics of colorectal cancer.

The role of UHRF1 in both normal and diseased states using mouse and colorectal cancer models

Computational analysis of cancer epigenome and transcriptome

The potential role of endogenous retrovirus for the activation of the immune system

Genome-wide localization of multivalent chromatin modifiers

Role of KDM2B in CpG island methylation in melanoma

The mechanisms of resetting genomic imprints in the male germline

Center for Neurodegenerative Science

Generating nanobodies as therapeutic approaches for prion disease

The role of VPS35 in Parkinson’s disease

Functional interactions of genes that cause Parkinson’s disease

Defining LRRK2 substrates/interactors and pathways of neurotoxicity

Investigating DNA methylation patterns that drive neuropathology in Parkinson’s disease patients

Computational analysis of epigenomics in neurodegenerative diseases

Lee Marshall, Ph.D.
Labrie Laboratory

Generating in vivo models in Parkinson’s disease

The role of synuclein prion strains in synucleinopathies and repurposing anti-diabetic drugs for the treatment of Parkinson’s disease and multiple system atrophy

Computational methods to identify genetic predispositions to breast cancer or Parkinson’s

Immunotherapy for minimizing alpha-synuclein propagation

The role of inflammation and tryptophan metabolism in the etiology of depressive disorders

The spread of alpha-synuclein pathology in the brain in Parkinson’s disease

The “prion-like” spread of toxicity in Parkinson’s disease

The influence of PLA2G6 on alpha-synuclein aggregation


Structure and function of membrane proteins

The role of the tumor microenvironment in prostate cancer metastasis

Structural and functional studies of membrane proteins using single particle electron cyro-microscopy.

Megan Michalski, D.D.S., Ph.D.
Williams Laboratory

Targeting receptor tyrosine kinases in breast cancer patient-derived xenografts to improve therapeutic strategies

Membrane protein structure and function

DNMT-nucleosome complexes and PRC2-nucleosome complex