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Meet the Postdocs

Working on an individual personalized project under the guidance of a qualified faculty mentor, VARI’s exceptional postdoctoral fellows make great contributions to the science conducted in the Institute’s laboratories. They play a crucial role in the intellectual development and management of research projects and contribute to a considerable share of the hands-on research activities in the laboratory.

VARI Fellows

DNA methylation modulation and epigenetic alterations in leukemogenesis

Center for Epigenetics

Single-cell and cell-free DNA methylation analysis in cancer

Epigenetic alterations that contribute to human disease

How chemical modifications on DNA and histone proteins influence the role of epigenetic regulatory proteins in development and cancer

Pan-cancer analysis based on dynamic epigenetic modifications

Molecular mechanisms of DNA replication

Investigating the relationship between H2A.Z deposition and DNA methylation

DNA methylation and the role of 5-hydroxymethylcytosine in cancer

Epigenetics of colorectal cancer

The role of UHRF1 in both normal and diseased states using mouse and colorectal cancer models

Epigenetic mechanisms and ion channels

Computational analysis of cancer epigenome and transcriptome

The potential role of endogenous retrovirus for the activation of the immune system

Genome-wide localization of multivalent chromatin modifiers

Role of KDM2B in CpG island methylation in melanoma

Histone reader and epigenetic modifications in cancer

Structural basis of DNA replication and the bacterial proteasome system using cryo-EM

The mechanisms of resetting genomic imprints in the male germline

Center for Neurodegenerative Science

Re-purposing anti-diabetic drugs for the treatment of Parkinson’s disease

The role of VPS35 in Parkinson’s disease

Wei Cui, Ph.D.
Labrie Laboratory

Functional interactions of genes that cause Parkinson’s disease

Defining LRRK2 substrates/interactors and pathways of neurotoxicity

The role of lysosomal protein ATP13A2 in alpha-synuclein propagation

Investigating DNA methylation patterns that drive neuropathology in Parkinson’s disease patients

Computational analysis of epigenomics in neurodegenerative diseases

Dr. Lee Marshall

Epigenetic and transcriptional dysregulation in Parkinson’s disease

Generating in vivo models in Parkinson’s disease

The role of synuclein prion strains in synucleinopathies and repurposing anti-diabetic drugs for the treatment of Parkinson’s disease and multiple system atrophy

Computational methods to identify genetic predispositions to breast cancer or Parkinson’s

Immunotherapy for minimizing alpha-synuclein propagation

The influence of PLA2G6 on alpha-synuclein aggregation

CENTER FOR CANCER AND CELL BIOLOGY

Structure-function studies of membrane proteins

Structure and function of membrane proteins

The role of the tumor microenvironment in prostate cancer metastasis

Structural and functional studies of membrane proteins using single particle electron cyro-microscopy.

Wnt signaling in craniofacial bone development

Payton Stevens

Wnt/Frizzled receptor signaling during pancreatic cancer progression

Targeting receptor tyrosine kinases in breast cancer patient-derived xenografts to improve therapeutic strategies

DNMT-nucleosome complexes and PRC2-nucleosome complex