Department of Neurodegenerative Science

The Department of Neurodegenerative Science focuses on elucidating disease mechanisms and identifying novel disease-modifying therapeutic approaches for major neurodegenerative diseases, with a special focus on Parkinson’s disease. Additional areas of interest include dementias (Alzheimer’s disease, dementia with Lewy bodies) and psychiatric disorders (depression, anxiety). Department faculty have research interests and expertise in the molecular underpinnings of neurodegenerative disease through an understanding of genetic risk, epigenetics, cell biology, biomarkers, neuropathology, neuroinflammation, neural circuits and patient-derived biospecimens. Their mission is to leverage new knowledge for the development of treatments for Parkinson’s and related disorders. 

Faculty

Recent Publications

Dehghani N, Guven G, Kun-Rodrigues C, Gouveia C, Foster K, Hanagasi H, Lohmann E, Samanci B, Gurvit H, Bilgic B, Brás J, Guerreiro R. 2021. A comprehensive analysis of copy number variation in a Turkish dementia cohort. Hum Genom 15:48.

Cornblath EJ, Li HL, Changolkar L, Zhang B, Brown HJ, Gathagan RJ, Olufemi MF, Trojanowski JQ, Bassett DS, Lee VYM, Henderson MX. 2021. Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor. Sci Adv 7(24):eabg6677.

Messerschmidt C, . . ., Brás J, Guerreiro R, Beule D, Dirnagl U, Sassi C. 2021. PHACTR1 genetic variaiblity is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice. Sci Rep.

Bacelis J, Compagno M, George S, Pospisilik A, Brundin P, Torinsson A, Brundin L. 2021. Decreased risk of Parkinson’s disease after rheumatoid arthritis diagnosis: a nested case-control study with matched cases and controls. J Parkinson’s Dis.

Henderson MX, Changolkar L, Trojanowski JQ, Lee VMY. In press. LRRK2 kinase activity does not alter cell-autonomous tau pathology development in primary neurons. J Parkinson’s Dis.

Dehghani N, Brás J, Guerreiro R. 2021. How understudied populations have contributed to our understanding of Alzheimer’s disease genetics. Brain.

Li P, Killinger BA, Ensink E, Beddows I, Yilmaz A, Lubben N, Lamp J, Schilthuis M, Vega IE, Woltjer R, Pospisilik JA, Brundin P, Brundin L, Graham SF, Labrie V. 2021. Gut microbiota dysbiosis is associated with elevated bile acids in Parkinson’s disease. Metabolites 11(1):29.

Sha Q, Achtyes E, Nagalla M, Keaton A, Smart L, Leach R, Brundin L. 2021. Associations between estrogen and progesterone, the kynurenine pathway, and inflammation in the post-partum. J Affect Dis 281:9–12.

Brundin P, Nath A, Beckham JD. 2020. Is COVID-19 a perfect storm for Parkinson’s disease?  Trends Neurosci.