Epigenetic mechanisms control how DNA is used, how organisms form, and how cells switch particular genes “on” or “off” to determine form and function. Errors in these intricate processes play major roles in the development of diseases like cancer, Parkinson’s, diabetes and heart disease.
Scientists in the Center for Epigenetics investigate the role of epigenetics in health and disease, with the goal of developing new prevention and treatment strategies for diseases that affect millions of people around the world.
Wan L, Chong S, Xuan F, Liang A, Cui X, Gates L, Carroll TS, Li Y, Feng L, Chen G, Wang SP, Ortiz WV, Saley SK, Wang X, Xuan H, Kentsis A, Muir TW, Roeder RG, Li H, Li W, Tijan R, Wen H, Allis CD. 2019. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature 577:121–126.
George JW, Fan H, Johnson B, Carpenter TJ, Foy KK, Chatterjee A, Patterson AL, Koeman J, Adams M, Madaj ZB, Chesla D, Marsh EE, Triche TJ, Shen H, Teixeira JM. 2019. Integrated epigenome, exome, and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids. Cell Rep.
Klein BJ, Jang SM, Lachance C, Mi W, Lyu J, Sakuraba S, Krajewski K, Wang WW, Sidoli S, Liu J, Zhang Y, Wang X, Warfield BM, Kueh AJ, Voss AK, Thomas T, Garcia BA, Liu WR, Strahl BD, Kono H, Li W, Shi X, Côté J, Kutateladze TG. 2019. Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Nat Commun 10(1):4724.
Colino-Sanguino Y, Cornett EM, Moulder D, Smith GC, Hrit J, Cordeiro-Spinetti E, Vaughan RM, Krajewski K, Rothbart SB*, Clark SJ*, Valdés-Mora F*. 2019. A read/write mechanism connects p300 Bromodomain function to H2A.Z acetylation. iScience S2589-0042(19)30434-1.
Milliron HY, Weiland MJ, Kort EJ, Jovinge S. 2019. Isolation of cardiomyocytes undergoing mitosis with complete cytokinesis. Circ Res.
March 2, 2020
Mark your calendars for the 2020 Origins of Cancer symposium!
Origins of Cancer is a one-day symposium that brings together students, scientists and medical professionals to discuss the latest breakthroughs in cancer research. This year’s meeting will highlight the tumor macroenvironment, which comprises near and far cells, tissues and systems that interact with primary cancer cells to promote tumor survival. Invited speakers also will discuss novel and integrative treatment approaches that target this larger interactome to outsmart cancer cells.
Feb. 28, 2020
Save the date for Epigenetics at VAI!
Epigenetics at VAI, is a bi-annual symposium and workshop hosted by Van Andel Institute, will be held Aug. 2–5, 2021. The theme for the 2021 symposium will be 20 Years of the Histone Code. For more information, please visit epigeneticsatvai.org. To be added to our scientific events email list, please email Beth Resau at Beth.Resau@vai.org.