Center for Epigenetics

Epigenetic mechanisms control how DNA is used, how organisms form, and how cells switch particular genes “on” or “off” to determine form and function. Errors in these intricate processes play major roles in the development of diseases like cancer, Parkinson’s, diabetes and heart disease.

Scientists in the Center for Epigenetics investigate the role of epigenetics in health and disease, with the goal of developing new prevention and treatment strategies for diseases that affect millions of people around the world.


Recent Publications

Kong X*, Chen J*, Xie W*, Brown SM, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann RL, Tao Y, Yen RWC, Topper MJ, Zahnow CA, Easwaran H, Rothbart SB#, Xia L#, Baylin SB#. 2019. Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties. Cancer Cell.
*These authors contributed equally
#Co-corresponding authors

Triska P, Kaneva K, Merkurjev D, Sohail N, Falk MJ, Triche Jr. J, Biegel JA, Gai X. 2019. Landscape of germline and somatic mitochondrial DNA mutations in pediatric malignancies. Cancer Res.

Yim JH, Choi AH, Li AX, Qin H, Chang S, Tong ST, Chu P, Kim BW, Schmolze D, Lew R, Ibrahim Y, Poroyko VA, Salvatierra S, Baker A, Wang J, Wu X, Pfeifer GP, Fond Y, Hahn MA. 2019. Identification of tissue-specific DNA methylation signatures for thyroid nodule diagnostics. Clin Cancer Res 25(2):544–551.

Kort EJ, Jovinge S. 2019. Streamlined analysis of LINCS L1000 data with the slinky package for R. Bioninformatics.

Zhang Y, Mi W, Xue Y, Shi X, Kutateladze TG. 2019. The ZZ domain as a new epigenetic reader and degradation signal sensor. Crit Rev Biochem Mol Biol 1–10.


Save the date for Epigenomics at VARI symposium and graduate student workshop
Mark your calendars for the 2019 Epigenomics at VARI intensive workshop for advanced graduate students, which will be held July 29–Aug. 2 at the Institute! Taught by internationally recognized epigenomics experts, Epigenomics at VARI gives gifted graduate students an intense overview of the latest innovative methodology and its applications across several fields including cancer and neurodegenerative disease research. The application period opens March 1 and closes May 1. Learn more here.

At the start of the workshop, The Institute will host a one-day symposium on July 29. Registration opens in May. Learn more about the speakers here.

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