Epigenetic mechanisms control how DNA is used, how organisms form, and how cells switch particular genes “on” or “off” to determine form and function. Errors in these intricate processes play major roles in the development of diseases like cancer, Parkinson’s, diabetes and heart disease.
Scientists in the Center for Epigenetics investigate the role of epigenetics in health and disease, with the goal of developing new prevention and treatment strategies for diseases that affect millions of people around the world.
Klein BJ, Jang SM, Lachance C, Mi W, Lyu J, Sakuraba S, Krajewski K, Wang WW, Sidoli S, Liu J, Zhang Y, Wang X, Warfield BM, Kueh AJ, Voss AK, Thomas T, Garcia BA, Liu WR, Strahl BD, Kono H, Li W, Shi X, Côté J, Kutateladze TG. 2019. Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Nat Commun 10(1):4724.
Colino-Sanguino Y, Cornett EM, Moulder D, Smith GC, Hrit J, Cordeiro-Spinetti E, Vaughan RM, Krajewski K, Rothbart SB*, Clark SJ*, Valdés-Mora F*. 2019. A read/write mechanism connects p300 Bromodomain function to H2A.Z acetylation. iScience S2589-0042(19)30434-1.
Milliron HY, Weiland MJ, Kort EJ, Jovinge S. 2019. Isolation of cardiomyocytes undergoing mitosis with complete cytokinesis. Circ Res.
Hahn MA, Jin SG, Li AX, Liu J, Huang Z, Wu X, Byung-Wook K, Johnson J, Bilbao ADV, Tao S, Yim JA, Fong Y, Goebbels S, Schwab MH, Lu Q, Pfeifer GP. 2019. Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation. Sci Adv 5(10):eaax0080.
Marinkovic G, Larsen HG, Yndigegn T, Szabo IA, Mares RG, de Camp L, Weiland M, Tomas L, Goncalves I, Nilsson J, Jovinge S, Schiopu A. 2019. Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction. Eur J Heart 40(32):2713–2723.
Save the date for Epigenomics at VARI symposium and graduate student workshop
Mark your calendars for the 2019 Epigenomics at VARI intensive workshop for advanced graduate students, which will be held July 29–Aug. 2 at the Institute! Taught by internationally recognized epigenomics experts, Epigenomics at VARI gives gifted graduate students an intense overview of the latest innovative methodology and its applications across several fields including cancer and neurodegenerative disease research. The application period opens March 1 and closes May 1. Learn more here.
At the start of the workshop, The Institute will host a one-day symposium on July 29. Registration opens in May. Learn more about the speakers here.
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