The Department of Epigenetics seeks to understand the plasticity of our genomes, and how our genetic output can be stably modified to protect us from or predispose us to complex disease such as cancer, infection, obesity and Parkinson’s. Faculty investigate the molecular processes that fine-tune how DNA is packaged, and how this packaging is stabilized to form disease programs. In this way, they will mine the origins of these complex diseases, mapping them to genetic and environmental inputs now, in our early lives, and even before birth.
Dickson BM, Tiedemann RL, Chomiak AA, Cornett EM, Vaughan RM, Rothbart SB. 2020. A physical basis for quantitative ChIP-sequencing. J Biol Chem.
*Selected as an Editor’s Pick and featured on the cover
Zhou W, Liang G, Molloy PL, Jones PA. 2020. DNA methylation enables transposable element-driven genome expansion. Proc Natl Acad Sci U S A 117(32):19359–19366.
Ohtani H … Jones PA, Grønbæk K. 2020. Activation of a subset of evolutionarily young transposable elements and innate immunity are linked to clinical responses to 5-azacytidine. Cancer Res 80(12):2441–2450.
Smith JL…Triche Jr TJ…Meshinchi S. 2020. Comprehensive transcriptome profiling of cryptic CBFA2T3–GLIS2 fusion–positive AML defines novel therapeutic options: A COG and TARGET pediatric AML study. 2020. Clin Can Res.
Pfeifer GP, Szabó PE, Song J. 2020. Protein interactions at oxidized 5-methylcytosine bases. J Mol Biol 432(6):1718-1730.
Kupai A, Vaughan RM, Dickson BM, Rothbart SB. 2020. A degenerate peptide library approach to reveal sequence determinants of methyllysine-driven protein interactions. Front Cell Dev Biol.