Epigenetic mechanisms control how DNA is used, how organisms form, and how cells switch particular genes “on” or “off” to determine form and function. Errors in these intricate processes play major roles in the development of diseases like cancer, Parkinson’s, diabetes and heart disease.
Scientists in the Center for Epigenetics investigate the role of epigenetics in health and disease, with the goal of developing new prevention and treatment strategies for diseases that affect millions of people around the world.
Pai S, Li P, Killinger B, Marshall L, Jia P, Liao J, Petronis A, Szabo PE, Labrie V. 2019. Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis. Nat Commun 10(1):2046.
Kong X*, Chen J*, Xie W*, Brown SM, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann RL, Tao Y, Yen RWC, Topper MJ, Zahnow CA, Easwaran H, Rothbart SB#, Xia L#, Baylin SB#. 2019. Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties. Cancer Cell.
*These authors contributed equally
Tarnawski L, Eugster E, DeCamp L, Jovinge S. 2019. The efficacy and safety of Sendai viral reprogramming of mouse primary cells using human vectors. Cell Reprogram 21(2):78–88.
Jones PA, Ohtani H, Chakravarthy A, DeCarvalho DD. 2019. Epigenetic therapy in immune-oncology. Nat Rev Cancer 19(3):151–161.
Gao G, Zhang L, Villarreal OD, He W, Su D, Bedford E, Moh P, Shen J, Shi X, Bedford MT, Xu H. 2019. PRMT1 loss sensitizes cells to PRMT5 inhibition. Nucleic Acids Res.
Save the date for Epigenomics at VARI symposium and graduate student workshop
Mark your calendars for the 2019 Epigenomics at VARI intensive workshop for advanced graduate students, which will be held July 29–Aug. 2 at the Institute! Taught by internationally recognized epigenomics experts, Epigenomics at VARI gives gifted graduate students an intense overview of the latest innovative methodology and its applications across several fields including cancer and neurodegenerative disease research. The application period opens March 1 and closes May 1. Learn more here.
At the start of the workshop, The Institute will host a one-day symposium on July 29. Registration opens in May. Learn more about the speakers here.
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