Our health, and consequently our lives, depend on the coordinated activities of our individual cells; diseases arise when the activities of these individual cells become derailed. Through our combined expertise in different cell types and communication mechanisms and using state-of-the-art approaches, scientists in VAI’s Department of Cell Biology pursue fundamental research to understand how our cells grow, communicate, survive, assemble into tissues and organs, respond to the environment, and change with age. This transformative work will yield new diagnostic and treatment strategies to improve the quality of life for people with cancer, bone diseases and rare disorders.
Liu Y, Molchanov V, Yang T. 2021. Enzymatic machinery of ubiquitin and ubiquitin-like modification systems in chondrocyte homeostasis and osteoarthritis. Curr Rheumatol Rep 23:62.
Zhong ZA, Michalski, MN, Stevens PD, Sall EA, Williams BO. 2021. Regulation of Wnt receptor activity: Implications for therapeutic development in colon cancer. J Biol Chem:100782.
McDowell CT, Klamer Z, Hall J, West CA, Wisniewski L, Powers TW, Angel P, Mehta AS, Lewin DN, Haab BB, Drake R. 2020. Imaging mass spectrometry and lectin analysis of N-linked glycans in carbohydrate antigen defined pancreatic cancer tissues. Mol Cell Proteomics 20:100012.
*Highlighted by ASBMBToday
Grit JL, Johnson BK, Dischinger PS, Essenburg CJ, Adams M, Campbell S, Pollard K, Pratilas CA, Triche TJ Jr., Graveel CR, Steensma MR. 2021. Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling. Epi Chromatin 14(7).