Scientists in the Institute’s Center for Cancer and Cell Biology investigate the mechanisms that give rise to diseases such as cancer, osteoporosis, osteoarthritis, diabetes and rare disorders such neurofibromatosis type 1 with the goal of developing better diagnostics and treatments.
Choi W#, Clemente N#, Sun W, Du J*, Lü W*. 2019. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature.
Zhao LH*, Ma S*, Sutkeviciute I*, Shen DD*, Zhou XE, de Waal PW, Li CH, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanbe T, Gradella TJ, Melcher K, Wang MW#, Vilardaga JP#, Xu HE#, Zhang Y#. 2019. Structure and dynamics of the active human parathyroid hormone receptor-1. Science.
* Equal contributions
# Co-corresponding authors
Saibil SD*, St. Paul *, Laister RC, Garcia-Batres CR, Israni-Winger K, Elford AR, Grimshaw N, Robert-Tissot C, Roy DG, Jones RG, Nguyen LT, Ohashi PS. 2019. Activation of peroxisome proliferator activated receptors α and δ synergizes with inflammatory signals to enhance adoptive cell therapy. Cancer Res 79(3):445–451.
Yan Y, Zhou EX, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K. 2019. Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated and nucleotide-free states. J Biol Chem 294(3):953–967.
Klamer Z, Hsueh P, Ayala-Talavera D, Haab BB. 2019. Deciphering protein glycosylation by computational integration of on-chip profiling, glycan-array data, and mass spectrometry. Mol Cell Proteomics 18(1):28-40.
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