Scientists in the Institute’s Center for Cancer and Cell Biology investigate the mechanisms that give rise to diseases such as cancer, osteoporosis, osteoarthritis, diabetes and rare disorders such neurofibromatosis type 1 with the goal of developing better diagnostics and treatments.
Choi W#, Clemente N#, Sun W, Du J*, Lü W*. 2019. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature.
Zhao LH*, Ma S*, Sutkeviciute I*, Shen DD*, Zhou XE, de Waal PW, Li CH, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanbe T, Gradella TJ, Melcher K, Wang MW#, Vilardaga JP#, Xu HE#, Zhang Y#. 2019. Structure and dynamics of the active human parathyroid hormone receptor-1. Science.
* Equal contributions
# Co-corresponding authors
Saibil SD*, St. Paul *, Laister RC, Garcia-Batres CR, Israni-Winger K, Elford AR, Grimshaw N, Robert-Tissot C, Roy DG, Jones RG, Nguyen LT, Ohashi PS. 2019. Activation of peroxisome proliferator activated receptors α and δ synergizes with inflammatory signals to enhance adoptive cell therapy. Cancer Res 79(3):445–451.
Yan Y, Zhou EX, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K. 2019. Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated and nucleotide-free states. J Biol Chem 294(3):953–967.
Klamer Z, Hsueh P, Ayala-Talavera D, Haab BB. 2019. Deciphering protein glycosylation by computational integration of on-chip profiling, glycan-array data, and mass spectrometry. Mol Cell Proteomics 18(1):28-40.
March 2, 2020
Mark your calendars for the 2020 Origins of Cancer symposium!
Origins of Cancer is a one-day symposium that brings together students, scientists and medical professionals to discuss the latest breakthroughs in cancer research. This year’s meeting will highlight the tumor macroenvironment, which comprises near and far cells, tissues and systems that interact with primary cancer cells to promote tumor survival. Invited speakers also will discuss novel and integrative treatment approaches that target this larger interactome to outsmart cancer cells.
Open positions in the Center for Cancer and Cell Biology
You can view all of the Institute’s job postings here.
Did you know?
Van Andel Institute Graduate School offers a rigorous, research-intensive Ph.D. program in molecular and cellular biology. Learn more here.