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The whole of epigenetic regulation may be greater than the sum of its parts

Vitamin C may boost effectiveness of acute myeloid leukemia treatment

The investigators urge patience and caution patients to wait for the results of the clinical trial.

New model recreates early spread of

Parkinson’s disease in the brain

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Reduced activity of an important enzyme identified among suicidal patients

Through biomedical research and science education Van Andel Institute is committed to improving the health and enhancing the lives of current and future generations.

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Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
Joseph S. Harrison, Evan M. Cornett, Dennis Goldfarb, Paul A. DaRosa, Zimeng M. Li, Feng Yan, Bradley M. Dickson, Angela H. Guo, Daniel V. Cantu, Lilia Kaustov, Peter J. Brown, Cheryl H. Arrowsmith, Dorothy A. Erie, Michael B. Major, Rachel E. Klevit, Krzysztof Krajewski, Brian Kuhlman, Brian D. Strahl, and Scott B. Rothbart
2016 | eLife

Mice with a heterozygous Lrp6 deletion have impaired fracture healing
Travis A. Burgers, Juan F. Vivanco, Juraj Zahatnansky, Andrew J. Vander Moran, James J. Mason, and Bart O. Williams
2016 | Bone Research

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
Nolwen L. Rey, Jennifer A. Steiner, Nazie Maroof, Kelvin C. Luk, Zachary B. Madaj, John Q. Trojanowski, Virginia M.-Y. Lee, and Patrik Brundin
2016 | Journal of Experimental Medicine