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Novel mechanisms of genetic instability in cancer Repetitive sequences have the capacity to adopt alternative DNA structures (e.g. H-DNA and Z-DNA) and stimulate genetic instability in the absence of exogenous DNA damage. However, the biological significance and the mechanisms of this DNA-structure-induced genetic instability are unknown. Here, we report that H-DNA- and Z-DNA-forming sequences are enriched at translocation breakpoints in human cancer genomes, implicating them in cancer etiology. We found that H-DNA-induced mutations were suppressed in human cells deficient in…Find out more »
PI 3-kinase and cancer metabolism Lewis Cantley, Ph.D., has made significant advances in cancer research stemming from his discovery of the signaling pathway phosphoinositide 3-kinase (PI3K) in 1984. The author of more than 400 original papers, 50 book chapters and review articles, Dr. Cantley is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Science, the Institute of Medicine of the National Academies, and the European life sciences academy EMBO. He…Find out more »
Title TBD Speaker Information Susanna Greer, Ph.D. Director, Clinical Cancer Research, Nutrition and Immunology American Cancer Society Time & Location 12:00 pm on Zoom VAI Host: Graduate Student Association, Katie Hollis Questions? For questions, please contact Kim Cousineau at 616.234.5684.Find out more »
Title TBD Speaker Information Sharona E. Gordon, Ph.D. Professor and Associate Dean for Research and Graduate Education University of Washington School of Medicine Time & Location 12:00 pm on Zoom VAI Host: Juan Du, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.Find out more »