Bone cancers and other skeletal diseases can be extremely painful and cause loss of mobility, which significantly reduces quality of life. While some treatments do exist, more research is needed to find new prevention strategies and improved therapies for these diseases.
Scientists in the Skeletal Disease and Cancer Therapeutics Program study the full spectrum of bone biology, from the mechanisms that give rise to healthy bone tissue to those that cause disease, with the goal of developing new, more effective treatments. These conditions include neurofibromatosis type 1, osteoporosis, osteoarthritis, and developmental disorders in addition to bone cancers, such as Ewing sarcoma and osteosarcoma, and bone metastases.
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Bergsma A, Ganguly SS, Dick D, Williams BO, Miranti CK. 2018. Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis. Bone 113:105–113.
Peacock JD, Pridgeon MG, Tovar EA, Essenburg CJ, Bowman M, Madaj Z, Koeman J, Boguslawski EA, Grit J, Dodd RD, Khachaturov V, Cardona DM, Chen M, Kirsch DG, Maina F, Dono R, Winn ME, Graveel CR, Steensma MR. 2018. Genomic status of MET potentiates sensitivity to MET and MEK inhibition in NF1-related malignant peripheral nerve sheath tumors. Cancer Res 78(13):3672–3687.
March 2, 2020
Mark your calendars for the 2020 Origins of Cancer symposium!
Origins of Cancer is a one-day symposium that brings together students, scientists and medical professionals to discuss the latest breakthroughs in cancer research. This year’s meeting will highlight the tumor macroenvironment, which comprises near and far cells, tissues and systems that interact with primary cancer cells to promote tumor survival. Invited speakers also will discuss novel and integrative treatment approaches that target this larger interactome to outsmart cancer cells.
Did you know?
Van Andel Institute Graduate School offers a rigorous, research-intensive Ph.D. program in molecular and cellular biology. Learn more here.