Dr. Zhaoyu Xue earned his B.S. in biology from Shandong University and his Ph.D. in molecular and developmental biology from Tsinghua University. His graduate work focused on CRISPR/Cas9 mediated genome editing and functional research of histone modifications in Drosophila. Along with his other research, he is familiar with fly genetics, immunohistochemistry and microscopy. In 2018, he joined the laboratory of Dr. Xiaobing Shi at Van Andel Institute as a postdoctoral fellow.
Posttranslational modifications (PTMs) on histones are important epigenetic machinery that regulate chromatin-associated processes, such as transcription and DNA repair. The PTMs can change direct interaction between DNA and histones. Dysregulation of PTMs leads to developmental disorders and other diseases such as cancer. Histone PTMs are recognized by different kinds of protein domains, including simple “readers” of PTMs. Then, binding of effectors recruits chromatin remodeling complexes or transcriptional factors at chromatin. Therefore, identification of novel reader proteins is critical for understanding the function of histone modifications.
Ph.D. in molecular and developmental biology, Tsinghua University (Advisor: Dr. Guanjun Gao)
Thesis: Development of Drosophila Cas9 system and its application in probing the function of histone
B.S. in biology, Shandong University
National Postgraduate Scholarships (Tsinghua University) (2014)
Entrance Scholarship (Tsinghua University) (2012)
National Encouragement Scholarships for Under-Graduate Students (Shandong University) (2011)
National Encouragement Scholarships for Under-Graduate Students (Shandong University) (2009)
To view a list of selected publications click below.
Wen K, Yang L, Xiong T, Di C, Ma D, Wu M, Xue Z, Zhang X, Long L, Zhang W, Zhang J, Bi X, Dai J, Zhang Q, Lu ZJ, Gao G. 2016. Critical roles of long noncoding RNAs in Drosophila spermatogenesis. Genome Res 26:1233–1244.
Hu L, Xu J, Yin MX, Zhang L, Lu Y, Wu W, Xue Z, Ho MS, Gao G, Zhao Y, Zhang L. 2016. Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded. Cell Discov 2:15047.
Xue Z, Ren M, Wu M, Dai J, Rong YS, Gao G. 2014. Efficient gene knock-out and knock-in with transgenic Cas9 in Drosophila. G3 (Besthesda) 4:925–929.
Xue Z, Wu M, Wen K, Ren M, Long L, Zhang X, Gao G. 2014. CRISPR/Cas9 mediates efficient conditional mutagenesis in Drosophila. G3 (Besthesda) 4:2167–2173.