Zach DeBruine, Ph.D.

Zach DeBruine, Ph.D.
Postdoctoral fellow, Triche Laboratory


Dr. DeBruine earned his B.S. in biochemistry from Hope College, and his Ph.D. in cellular and molecular biology from Van Andel Institute Graduate School. His graduate work focused on the WNT signaling pathway, first using bottom-up structural and biochemical methods to understand molecular mechanisms of signal activation, and later using top-down bioinformatic methods to gain insights into signaling specificity. In 2021, he joined the laboratory of Dr. Tim Triche at Van Andel Institute as a postdoctoral fellow, in close collaboration with Dr. Andrew Pospisilik.


Current research focus

Dr. DeBruine’s work centers around a machine learning method known as Non-negative Matrix Factorization. He has developed the fastest implementation of this method, allowing it to be applied to big biological data of unprecedented scale to answer questions about cellular signaling networks, poorly understood biological processes, and genetic bases of phenotypic variation.