Yihe Huang, Ph.D.

Yihe Huang, Ph.D.
Postdoctoral fellow, Lü Laboratory


Dr. Yihe Huang earned Bachelor’s degrees in pharmacology and management from Shanxi University followed by a Ph.D. in biochemistry and molecular biology from Peking University. During his graduate studies in the lab of Dr. Xiao-Dong Su, Dr. Huang utilized X-ray crystallography to study the stringent response in Streptococcus mutans, a major contributor to tooth decay, as well as the role of STING in innate immunity. His efforts revealed the structures of the cytosolic domain of STING and its complex with c-di-GMP. He then joined the lab of Dr. Youxing Jiang at UT Southwestern Medical Center as a postdoctoral fellow, where he conducted extensive structural studies on membrane proteins, particularly eukaryotic sodium calcium exchanger. He later joined Dr. Kenneth Westover’s lab, also at UT Southwestern, to study non-receptor tyrosine kinases and expand his expertise in enzymology and cancer biology. In 2017, he began a postdoctoral fellowship in the lab of Dr. Wei Lü in Van Andel Institute’s Center for Cancer and Cell Biology.


Current research focus

Structural and functional studies of membrane proteins using single particle electron cyro-microscopy.


Postdoctoral fellowship, Department of Radiation Oncology, UT Southwestern Medical Center (Adviser: Dr. Kenneth Westover)

Postdoctoral fellowship, Department of Physiology, UT Southwestern Medical Center (Adviser: Dr. Youxing Jiang)

Ph.D., in biochemistry and molecular biology, Peking University (Adviser: Dr. Xiao-Dong Su)
Thesis: The structural basis for the sensing and binding of c-di-GMP by STING

B.S. in pharmacology, Shanxi University

B.S. in management, Shanxi University



Huang Y, Fliegert R, Guse AH, Lü W#, Du J#. 2019. A structural overview of the ion channels of the TRPM family. Cell Calcium.

Haung Y, Roth B, Lü W#, Du J#. 2019. Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. eLife.

Liao J, Marinelli F, Lee C, Huang Y, Faraldo-Gomez JD, Jiang Y. 2016. Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nat Struct Mol Biol 23(6):590 –599.

Huang YH, Liu XY, Du XX, Jiang ZF, Su XD. 2012. The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat Struct Mol Biol 19(7):728–730.