616.234.5000

Yanting Yin, Ph.D.

Yanting Yin, Ph.D.
Postdoctoral fellow, Huilin Li Laboratory
616.234.5372

Biography

Dr. Yanting Yin earned her B.S. from Tianjin University of Traditional Chinese Medicine and her Ph.D. in structural biology and pharmacology from Shanghai Institute of Materia Medica, a part of the Chinese Academy of Sciences. Her dissertation research, which was completed in the labs of Drs. H. Eric Xu and Karsten Melcher at SIMM and Van Andel Research Institute, focused on the structural basis of class B G protein-coupled receptors (GPCRs), a molecular family with significant drug development implications for diseases including heart failure and cancer. She is now a postdoctoral fellow in the lab of Dr. Huilin Li at VARI.

 

 

 

 

Current research focus

Dr. Yanting Yin uses cryo-electron microscopy (cryo-EM) to investigate the structural basis of DNA replication, including a ring-shaped protein called ORC, which helps initiate the replication process and unwind the DNA double helix. She also studies the bacterial proteasome system of Mycobacterium tuberculosis, a serious public health threat that claims between 1.5 and 2 million lives annually around the world.

Education & Training

Exchange graduate student, Van Andel Research Institute (Mentors: Dr. H. Eric Xu and Dr. Karsten Melcher)

Ph.D. in structural biology and pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (Adviser: Dr. H. Eric Xu)
Thesis: Structural and functional studies of class B G protein-coupled receptors

B.S. in Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine
Thesis: The pharmacokinetic study of ligustrazine

Awards & External Funding

Outstanding Graduates (2012)

Student Award for Research and Innovation (2012)

Grand Prize in The Contest for Creative Working of Tianjin College Students (2010)

National Scholarship (2010)

The First Prize Scholarship (2009–2012)

National Encouragement Scholarship (2009)

Publications

To view a list of selected publications click below.

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Yin Y,  de Waal PW, He Y, Zhao LH, Yang DH, Cai XQ, Jiang Y, Wang MW, Melcher K,  Xu HE. 2017. Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors. J Biol Chem 292(24):9865–9881.
*Featured on the cover and listed on F1000 Prime Recommendations

He Y, Gao X, Goswami D, Hou L, Pal K, Yin Y, Zhao G, Ernst O, Griffin P, Melcher K, Xu HE. 2017. Molecular assembly of rhodopsin with G-protein coupled receptor kinases. Cell Res 27(6):728–747.

Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Lubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE. 2017. Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors. Cell 170:457–469.
*Featured on the cover of Cell

Yin Y,  Zhou XE,  Hou L,  Zhao LH,  Liu B,  Wang G,  Jiang Y,  Melcher K,  Xu HE. 2016. An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain. Cell Discov 2:16042.

Zhao LH,  Yin Y, Yang D, Liu B,  Hou L, Wang X, Pal K, Jiang Y,  Feng Y,  Cai X,  Dai A,  Liu M, Wang MW, Melcher K,  Xu HE. 2016. Differential requirement of the extracellular domain in activation of class B G protein-coupled receptors. J Biol Chem 15119–15130.

Liu P, Jia M,  Zhou XE, De Waal PW, Dickson BM,  Liu B,  Hou L, Yin Y, Kang Y, Shi Y, Melcher K, Xu HE, Jiang Y. 2016. The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer. Acta Pharmacol Sin 37:1259–1272.