Dr. Valentín Cóppola Segovia earned his B.S. in biological sciences from the University of the Republic (Uruguay) and his M.S and Ph.D. in cell and molecular biology from the Federal University of Paraná (Brazil). His graduate work focused on endoplasmic reticulum stress as the main cause for endogenous alpha-synuclein aggregation in Parkinson’s disease. He has technical experience in experimental protocol design, cell culture, stereotaxic surgery and immunoassays. In 2019, he joined the laboratory of Dr. Darren Moore at Van Andel Institute as a postdoctoral fellow.
LRRK2 physically interacts with ArfGAP1, and both proteins are found together on Golgi membranes. ArfGAP1 activates LRRK2’s GTPase function, but LRRK2 also phosphorylates ArfGAP1, suggesting that both proteins may regulate each other. Currently, Dr. Valentin Cóppola Segovia is studying the relevance of ArfGAP1 phosphorylation in LRRK2-induced neurodegeneration in vitro and in vivo.
Ph.D. in cell and molecular biology, Federal University of Paraná (Brazil) (Advisor: Prof. Silvio Marques Zanata)
Thesis: Relevance of endoplasmic reticulum stress in alpha-synuclein aggregation in Parkinson’s disease
M.S. in cell and molecular biology, Federal University of Paraná (Brazil) (Advisor: Prof. Silvio Marques Zanata)
Thesis: Characterization of a new model of Parkinson’s disease based on endoplasmic reticulum stress
B.S. in biological sciences, University of the Republic (Uruguay)
Travel Award, The 41th Annual Meeting of the Japan Neuroscience Society (2018)
Travel Award, Young Scientist for the Selected Symposium at the SBBq-Conesul in the 46th Annual Reunion of the SBBq (Brazilian Society of Molecular Biology and Biochemistry) (2017)
To view a list of selected publications click below.
Machado MMF, Bassani TB, Cóppola-Segovia V, Moura ELR, Zanata SM, Andreatini R, Vital MABF. In press. PPAR-γ agonist pioglitazone reduces microglial proliferation and NF-κB activation in the substantia nigra in the 6-hydroxydopamine model of Parkinson’s disease. Pharmacol Rep.
Bassani, TB, Bonato JM, Machado MMF, Cóppola-Segovia V, Moura ELR, Zanata SM, Oliveira RMMW, Vital MABF. 2017. Decrease in adult neurogenesis and neuroinflammation are involved in spatial memory impairment in the streptozotocin-induced model of sporadic Alzheimer’s disease in rats. Mol Neurobiol 55(5):4280–4296.
Bassani TB, Turnes JM, Moura ELR, Bonato JM, Cóppola-Segovia V, Moura ELR, Zanata SM, Oliveira RMMW, Vital MABF. 2017. Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer’s type. Behav Brain Res 335:41–54.
Cóppola-Segovia V, Cavarsan C, Maia FG, Ferraz AC, Nakao LS, Lima MMS, Zanata SM. 2017. ER-stress induced by tunicamycin triggers α -synuclein oligomerization, dopaminergic neurons death and locomotor impairment: a new model of Parkinson’s disease. Mol Neurobiol 54:5798–5806.