Sushant Kumar, Ph.D.

Sushant Kumar, Ph.D.
Postdoctoral fellow, Du Laboratory
616.234.5867
 

Biography

Dr. Kumar earned his B.S. in agriculture from G.B. Pant University of Agriculture and Technology, India and M.S. in life sciences from Jawaharlal Nehru University, India. From 2011-17, he pursued his Ph.D. in molecular biophysics from Indian Institute of Science (IISc), Bangalore, India. His graduate work focused on studying the structure of DNA damage-inducing protein 1 from protozoans using x-ray crystallography and studying their interactions with inhibitors. Dr. Kumar also worked to understand the strain and pH-dependent structural changes in rotaviral enterotoxin NSP4. He characterized a Zn-bound single-chain camelid antibody raised against a secondary active transporter NorC from Methicillin-resistant Staphylococcus aureus and determined the X-ray structure of the transporter in complex with the camelid antibody. In 2021, he joined Van Andel Institute as a postdoctoral fellow in the lab or Dr. Juan Du.

 

Current research focus

Structure and function of ion channels using cryo-electron microscopy and electrophysiology.

Education & Training

Ph.D. in molecular biophysics, Indian Institute of Science, Bangalore, India (Prof. Kaza Suguna)
Thesis: Structural studies on DNA damage inducible protein 1 (Ddi1) of Leishmania and the rotavirus nonstructural protein NSP4

M.S. in life sciences, Jawaharlal Nehru University, New Delhi, India

B.S. in agriculture,  G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India

Awards & External Funding

Awarded DBT-IISc postdoctoral fellowship (2020)

International travel award for ‘Gordon Research Conference on Ligand recognition and molecular gating’ from Department of Science and Technology, Govt. of India (2020)

Best speaker award in the ‘National Seminar in Crystallography’ organized at NIMHANS, Bangalore, India (2018)

Awarded a Senior Research Fellowship by the Council of Scientific and Industrial Research, India (2013)

Awarded a Junior Research Fellowship by the Council of Scientific and Industrial Research, India (2011)

Awarded Junior Research Fellowship by Indian Council of Agricultural Research, India (2009)

National Talent Search Scholarship awarded by Indian Council of Agricultural Research, India (2005)

Publications

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Kumar S, Athreya A, Gulati A, Nair RM, Penmatsa A. 2020. Structural basis of inhibition of a putative drug efflux transporter NorC, through a single- domain camelid antibody. bioRxiv.

Kumar S, Mahendran I, Athreya A, Ranjan R, Penmatsa A. 2019. Isolation and structural characterization of a Zn2+-bound single-domain antibody against NorC, a putative multidrug efflux transporter in bacteria. J Biol Chem 295(1):55–68.

Kumar S, Suguna K. 2018. Crystal structure of the retroviral protease-like domain of a protozoal DNA damage-inducible 1 protein. FEBS Open Bio 8(9):1379–1394.

Kumar S, Ramappa R, Pamidimukkala K, Rao CD, Suguna K. 2018. New tetrameric forms of the rotavirus NSP4 with antiparallel helices. Arch Virol 163(6):1531–1547

Society Memberships

Indian Crystallographic Association