Qinglong You, Ph.D.
Biography
Dr. Qinglong You earned a B.S. in applied physics from Huazhong University of Science and Technology, and a Ph.D. in molecular biology and Bbiochemistry from the Institute of Biophysics of the Chinese Academy of Sciences. In his graduate work, Dr. You studied nucleosome binding proteins and mBend3 DNA complex with use of X-ray crystallography. Much of his laboratory work includes protein analysis and expression and crystal structure determination. In 2019, he joined the laboratory of Dr. Huilin Li at Van Andel Institute as a postdoctoral fellow.
Current research focus
The DNA damage repair process is very important for cells, and involves numerous proteins that recognize damaged DNA as part of the repair pathway. We are interested in complexes that play important roles in this pathway, and plan to use cryo-EM to investigate.
Education & Training
Ph.D. in molecular biology and biochemistry, Institute of Biophysics, Chinese Academy of Sciences (Advisor: Ruiming Xu)
Thesis: Structure of BEND3-DNA complex reveals a new modality of CpG DNA recognition by BEN domain proteins
B.S. in applied physics, Huazhong University of Science and Technology
Awards & External Funding
First prize of the National Scholarship (2009)
Outstanding Graduates Award, Huazhong University of Science and Technology (2012)
Publications
Bai L, You Q, Feng X, Kovach A, Li H. 2020. Structure of the ER membrane complex, a transmembrane-domain insertase. Nature.
Bai L, Kovach A, You Q, Hsu C, Zhao G, Li H. 2019. Autoinhibition and activation mechanisms of the eurkaryotic lipid flippase Drs2p-Cdc50p. Nat Commun 10(1):4142.
Bai L, Kovach A, You Q, Kenny A, Li H. 2019. Structure of the eukaryotic protein O-mannosyltransferase Pmt1−Pmt2 complex. Nat Struct Mol Biol.