Qing He, Ph.D.

Qing He, Ph.D.
Postdoctoral fellow, Melcher Laboratory

Biography

Dr. Qing He graduated from Shandong Normal University with a B.S. in biotechnology and Ph.D. in microbiology. Her graduate work focused on ­­­the structural and functional study of c-di-NMP related proteins, and the many biochemical experiments. Dr. He’s main lab competencies lie in ­­­cloning, protein purification, crystallization and small molecular and protein interaction tests. In 2021, she joined the lab of Dr. Karsten Melcher as a postdoctoral fellow.

 

Current research focus

Using cryo-EM and negative-staining, Dr. He investigates the structure and function of the MYC/JAZ/NINJA complex in order to elucidate interactions between JAZ and NINJA. Her work seeks to reveal the proposed transition from repressor to activator through altered interactions of a preassembled complex.

Education & Training

Ph.D. in microbiology, Shandong University (Adviser: Dr. Lichuan Gu)
Thesis: Structure and function of the pathogen proteins involved in cyclic dinucleotides metabolism and regulation

B.S. in biotechnology, Shandong Normal University

Awards & External Funding

National scholarship for doctoral student (2016)

Second academic scholarship of Shandong University (2015)

Publications

To view a list of selected publications click below.

Read More

Gu L, He Q. 2020. A unified catalytic mechanism for cyclic di-NMP hydrolysis by DHH–DHHA1 phosphodiesterases. Microbial Cyclic Di-Nucleotide Signaling:79–92).

Wang F*, He Q*, Yin J, Xu S, Hu Wei, Gu L. 2018. BrlR from Pseudomonas aeruginosa is a common receptor for both cyclic di-GMP and pyocyanin. Nat Commun 9:2563
*Equal contributions

He Q*, Wang F*, Liu S, Zhu D, Cong H, Gao F, Li B, Wang H, Lin Z, Liao J, Gu L. 2016. Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase. J Biol Chem 291(7):3668–3681.