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Miguel Angel Aguileta Estrada, Ph.D.

Miguel Angel Aguileta Estrada, Ph.D.
Postdoctoral fellow, Patrik Brundin Laboratory

Biography

Dr. Miguel Aguileta earned his B.Sc. in biomedical research from the National Autonomous University of Mexico, his M.Sc. in neuroscience from McGill University in Montreal, Canada and his Ph.D. in biotechnology from Ghent University, Belgium. During his graduate studies, Dr. Aguileta conducted research in different fields, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (Parkin and PINK1) and cell death mechanisms (intrinsic and extrinsic pathways). Dr. Aguileta pursued a brief (two-year) postdoctoral fellowship in Cologne, Germany, where he uncovered an immune response triggered by Huntingtin aggregates. In addition to his passion for investigating neurodegenerative diseases, he has a particular interest in posttranslational modifications. In 2019, he joined the laboratory of Dr. Patrik Brundin at Van Andel Institute as a postdoctoral fellow.

 

Current research focus

In the past decade, some of the genes linked to Parkinson’s disease have been found to have immune functions — some related to the suppression of self-antigens and some related to the dampening of viral infections. Since the vast majority of Parkinson’s cases are “sporadic,” it is worth testing whether infections can increase the risk, or even be causative, for Parkinson’s disease.

Education & Training

Ph.D. in biotechnology, Ghent University (Belgium) (Advisor: Dr. Mathieu Bertrand)

M.Sc. in neuroscience from McGill University (Advisor: Dr. Edward Fon)

B.S. in biomedical research, National Autonomous University of Mexico

Publications

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Aguileta MA, Rojas-Rivera D, Goossens V, Estornes Y, Van Isterdael G, Vandenabeele P, Bertrand MJ. 2016. A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress. Cell Death Differ 23(10):1670–1680.

Aguileta MA, Korac J, Durcan TM, Trempe JF, Haber M, Gehring K, Elsasser S, Waidmann O, Fon EA, Husnjak K. 2015. The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. J Biol Chem 290(12):7492–7505.

Estornes Y, Aguileta MA, Dubuisson C, De Keyser J, Goossens V, Kersse K, Samali A, Vandenabeele P, Bertrand MJ. 2014. RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions. Cell Death Dis 5:e1555.

Durcan TM, Tang MY, Pérusse JR, Dashti EA, Aguileta MA, McLelland GL, Gros P, Shaler TA, Faubert D, Coulombe B, Fon EA. 2014. USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin. EMBO J 33(21):2473–2491.

Dondelinger Y1, Aguileta MA1, Goossens V, Dubuisson C, Grootjans S, Dejardin E, Vandenabeele P, Bertrand MJ.  2013. RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death Differ 10:1381–1392.

Green AW, Grenier K, Aguileta MA, Muise S, Farazifard R, Haque ME, McBride HM, Park DS, Fon EA. 2012. Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep 4:378–385.

Ramirez-Jarquin JO, Lara-Hernandez S, Lopez-Guerrero JJ, Aguileta MA, Rivera-Angulo AJ, Sampieri A, Vaca L, Ordaz B, Pena-Ortega F. 2012. Somatostatin modulates generation of inspiratory rhythms and determines asphyxia survival. Peptides 2:360–372.

Zavala-Tecuapetla C, Aguileta MA, Lopez-Guerrero JJ, Gonzalez-Marin MC And Pena F. 2008. Calcium-activated potassium currents differentially modulates respiratory rhythm generation. Eur J Neurosci 11:2871–2884.

 Pena F, Aguileta MA. 2007. Effects of riluzole and flufenamic acid on eupnea and gasping of neonatal mice in vivo. Neurosci Lett 3:288–293.