616.234.5000

Michael Dahabieh, Ph.D.

Michael Dahabieh, Ph.D.
Postdoctoral fellow, Russell Jones Laboratory
616.234.5693

Biography

Dr. Michael Dahabieh earned his Ph.D. in experimental medicine from McGill University and his M.Sc. and B.Sc. in molecular biology and biochemistry from Simon Fraser University. His thesis research focused on the role of peroxisomes in tumor proliferation across multiple model systems. To aide in his research, he has laboratory skills that include immunoprecipitation, immunofluorescence, flow cytometry, electron microscopy, density centrifugation, among others. In 2020, Dr. Dahabieh continued his study of cancer and metabolism as a postdoctoral fellow in Dr. Russell Jones’ lab.

Current research focus

Upon pathogen infection and cancer, T cells possess the capacity to kill compromised target cells, ultimately clearing the body of disease. However, under conditions where infections and cancers persist, T cells exhibit exhaustion, characterized by decreased effector function, or reduced target killing. Dr. Dahabieh’s research focuses on better characterizing exhausted T cell populations, and ultimately aim to shift exhausted populations towards more effector-like states that thwart infections and cancers.

Education & Training

Ph.D. in experimental medicine, McGill University (Advisors: Dr. Sonia del Rincón and Dr. Wilson Miller, Jr.)
Thesis: Examining the effects of compromising peroxisomes upon therapy treatment in cancer

M.Sc. in molecular biology and biochemistry, Simon Fraser University     

B.Sc. in molecular biology and biochemistry, Simon Fraser University

Awards & External Funding

Fonds de recherche Santé Québec, two-year postdoctoral training award (April 2020)

Canadian Institute for Health Research (June 2018)

Canadian student health research forum

Gold medal, poster presentation

Lady Davis Institute Annual Retreat (May 2018)

1st place, poster presentation 

Canadian Cancer Society, Travel Award (Dec. 2017)

McGill, Experimental Medicine Travel Award (Dec. 2017)

McGill Integrated Cancer Research Training Program (Sept. 2017)                                    

Lady Davis Institute. Paper of the Month (Sept. 2017)                                                  

“Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis.” 

Lady Davis Institute Graduate Student Talks (April 2017)

Overall 1st place, oral presentation 

16th Annual McGill Biomedical Graduate Conference (March 2016)

2nd place, oral presentation

Lady Davis Institute Graduate Student Talks (May 2015)

Overall 1st place, oral presentation 

15th Annual McGill Biomedical Graduate Conference (March 2015)

Overall 1st place, poster prize

McGill, Experimental Medicine Travel Award (March 2015)

Lady Davis Institute Annual Retreat (May 2014)

Overall 1st place, oral presentation

Lady Davis Institute Graduate Student Talks (Feb. 2014)                  

Overall 1st place, oral presentation

Fonds de recherche Santé Québec, doctoral training award (June 2013) 

McGill Integrated Cancer Research Training Program (Dec. 2013)

McGill, Department of Medicine, Grad Excellence Award (Sept. 2013)

Chemical Institute of Canada, presentation award (June 2011)

Simon Fraser University NSERC Fellowship (Sept. 2011)

Simon Fraser University Graduate Student Fellowship (Jan. 2010)

Simon Fraser University, Dean’s Honour Roll (April 2008)

Publications

To view a list of selected publications click below.

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Yang W, Khoury E, Guo Q, Prabhu SA, Emond A, Huang F, Gonçalves C, Zhan Y, Plourde D, Nichol JN, Dahabieh MS, Miller WH Jr, Del Rincón SV. 2020. MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression. Oncogene 39(18):3650–3665.

Dahabieh MS, Di Pietro E, Jangal M, Goncalves C, Witcher M, Braverman N, del Rincón SV, Miller Jr. WH. 2018. Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism. Biochimica et Biophysica Acta: Reviews on Cancer.

Dahabieh MS, Ha Z, di Pietro E, Nichol JN, Bolt AM, Goncalves C, Dupéré-Richer D, Pettersson F, Mann KK, Braverman N, del Rincón SV, Miller Jr. W.H. 2017. Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis. Cell Death and Differentiation

Chang CH, Bijian K, Qiu D, Su J, Saad A, Dahabieh MS, Miller Jr WH, Alaoui-Jamali MA. 2017. Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells. Oncotarget,

Zhan Y, Dahabieh MS, Dobocan MC, M’Boutchou M, Goncalves C, Liu LS, Pettersson F, Rajakumar A, Topisirovic I, van Kempen L, del Rincón SV, Miller Jr WH. 2015.The role of eIF4E in response and acquired resistance to vemurafenib in melanoma. 2015. J Invest Dermatol 135:1368.

Garnier N, Gu Y, Redstone G, Dahabieh MS, Nichol JN, Bohle DS, Mann K, Miller Jr WH. 2013. The novel arsenical darinaparsin is transported by cysteine importing systems. Mol Pharmacol 85:576.

Dahabieh MS, Samanta D, Brodovitch JC, Frech C, Pinto BM, O’Neill MA. 2012. Sequence-dependent folding dynamics of primate A-to-I editing substrates. ChemBioChem 13:2714.

Prychyna O, Dahabieh MS, Chao J, O’Neill MA. 2009. Sequence-dependent folding and unfolding of ligand-bound purine riboswitches. Biopolymers 91:953.
*Journal front cover