Dr. Megan Michalski earned her Doctor of Dental Surgery (D.D.S.) degree and Ph.D. from University of Michigan, where her studies focused on the immune system’s role in bone turnover. She has been awarded numerous accolades for her scholarship, including the Russel W. Bunting Periodontal Society Award from University of Michigan School of Dentistry and a Ruth L. Kirschstein National Research Service Award (F30) from the National Institutes of Health. As a postdoctoral fellow in the lab of Dr. Bart Williams at Van Andel Institute, her work now focuses on the role of canonical and non-canonical Wnt signaling in craniofacial and tooth development.
Craniofacial development is a highly complex and coordinated process requiring crosstalk of several key signaling pathways. Decades of research have identified the Wnt signaling pathway as a crucial player in the proper development of the craniofacial skeleton and soft tissue. While Wnt molecules are known to be necessary for cranial bone formation, suture closure and palatal shelf fusion, little is known regarding the specific Wnt receptors that function during the development of cranial tissues.
Wnts signal through frizzled receptors, of which there are 10 family members. The role of the frizzled receptors is not well appreciated in craniofacial development, likely due to the overlapping functions of these receptors. We aim to determine specific frizzled receptors expressed during embryonic skull development and how they function to regulate proper tissue patterning.
D.D.S. and Ph.D. in oral health sciences, University of Michigan School of Dentistry (Adviser: Dr. Laurie McCauley)
Thesis: Macrophage contributions to bone turnover
B.A. in biochemistry and molecular biology, Cornell College
American Association for the Advancement of Science
American Society for Bone and Mineral Research
American Association for Dental Research
International Association for Dental Research
American Student Dental Association
Rackham Predoctoral Fellowship (2016–2017)
Ruth L. Kirchstein National Research Service Awards (NRSA) for Individual Fellowship (F30DE025154) (2015–2016)
Tissue Engineering and Regeneration (TEAM) Training Grant, National Institute for Dental and Craniofacial Research (NIDCR) (2010–2015)
AADR Hatton Competition Finalist, AADR/IADR Annual Meeting (2017)
Rackham Block Grant to attend ASBMR Annual Meeting, University of Michigan (2016)
Rackham Conference Travel Grant to attend ASBMR Annual Meeting, University of Michigan (2016)
Rackham Predoctoral Fellowship, University of Michigan (2016)
Gordon Research Travel Support to attend Gordon Research Seminar and Conference “Bones and Teeth” (2016)
Rackham Conference Travel Grant to attend Gordon Research Seminar and Conference “Bones and Teeth” (2016)
First place poster, Ph.D./Postdoctoral Fellow/Faculty/Staff Award Research Day, University of Michigan School of Dentistry (2016)
Endocrine Fellows Forum Travel Support to attend Endocrine Fellow Forum–ASBMR Meeting (2015)
Rackham Block Grant, University of Michigan to attend ASBMR Annual Meeting
Rackham Conference Travel Grant to attend IADR/AADR Annual Meeting (2015)
Second place poster, Ph.D./Postdoctoral Fellow/Faculty/Staff Award Research Day, University of Michigan School of Dentistry (2015)
Rackham Block Grant, University of Michigan to attend IADR/AADR Annual Meeting (2014)
Russell W. Bunting Periodontal Society Award, University of Michigan School of Dentistry (2014)
Phi Kappa Phi Honor Society, University of Michigan (2012)
Zhong ZA, Michalski, MN, Stevens PD, Sall EA, Williams BO. 2021. Regulation of Wnt receptor activity: Implications for therapeutic development in colon cancer. J Biol Chem:100782.
Michalski MN, McCauley LK. 2017. Macrophages and skeletal health. Pharmacol Ther 174:43–54.
Michalski MN, Koh AJ, Weidner S, Roca H, McCauley LK. 2016. Modulation of osteoblastic cell efferocytosis by bone marrow macrophages. J Cell Biochem 117(12):2697–2706.
Cho SW, Pirih FQ, Michalski M, Eber M, Ritchie K, Sinder B, Oh S, Lee J, Kozloff K, Danciu T, Wronski T, McCauley LK. 2013. Soluble interleukin-6 receptor signaling is a mediator of hematopoietic and skeletal actions of parathyroid hormone. J Biol Chem 288:6814–6825.
Novince CM, Entezami P, Wilson CG, Wang J, Koh AJ, Michalski MN, Sinder BP, Kozloff KM, Taichman RS, McCauley LK. The impact of proteoglycan-4 and parathyroid hormone on articular cartilage degeneration. J Ortho Res 31(2):183–190.
Park SI, Liao J, Berry J, Li X, Koh A, Michalski M, Eber M, Soki F, Sadler W, Sud S, Tisdelle S, Daignault SD, Nemeth J, Snyder L, Wronski T, Pienta K, McCauley LK. 2012. Cyclophosphamide creates a responsive microenvironment for prostate cancer skeletal metastasis. Cancer Res 72(10):2522–2532.
Novince CM, Michalski MN, Sinder BP, Entezami P, Koh AJ, Eber MJ, Pettway GJ, Rosol TJ, Wronski TJ, Kozloff KM, McCauley LK. 2012. Proteoglycan-4: a dynamic regulator of skeletogenesis and PTH skeletal anabolism. J Bone Miner Res 27(1):11–25.
Novince CM, Koh AJ, Michalski MN, Marchesan JT, Wang J, Jung Y, Berry JE, Eber MR, Rosol TJ, Taichman RT, McCauley LK. 2011. Proteoglycan-4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells. Am J Pathol 179(5):2431–2442.
Pirih F, Michalski M, Koh A, Berry J, Ghaname E, Kamarajan P, Bonnelye E, Ross C, Kapila Y, Jurdic P, McCauley LK. 2010. Parathyroid hormone mediates hematopoietic cell expansion through Interleukin-6. PloS One 5(10):e13657.