Dr. Longxia Xu earned a B.S. in biotechnology from Southwest University and a Ph.D. in biochemistry and molecular biology from Shanghai Institute. Dr. Xu’s undergraduate work focused on in vivo integrations, followed by graduate work that explored the role of histone H3k27me3 demethylase in lung carcinogens and the function of skin development. In 2018, Dr. Xu joined the laboratory of Dr. Xiaobing Shi at Van Andel Institute as a postdoctoral fellow.
My current study focuses on finding novel histone readers and understanding their function in carcinogenesis in an effort to find potential drug target.
Ph.D. in biochemistry and molecular bology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science (Advisor: Charlie Degui Chen, Ph.D.)
Thesis: The function of histone demethylase JMJD3 in cell fate determination
B.S. in biotechnology, Southwest University
Outstanding student of University of the Chinese Academy of Sciences (2015)
Outstanding Graduate of Southwest University (2010)
National Scholarship of China (2008)
National Scholarship of China (2007)
To view a list of selected publications click below.
Zhang, F, Xu, L, Xu, L, Xu, Q, Li, D, Yang, Y, Karsenty, G, and Chen, C. D. 2015. JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol 7(1):23–34.
Zhang, F, Xu, L, Xu, L, Xu, Q, Karsenty, G, and Chen, C. D. 2015. Histone demethylase JMJD3 is required for osteoblast differentiation in mice. Sci Rep 5:13418.
Liu, Z, Cao, W, Xu, L, Chen, X, Zhan, Y, Yang, Q, Liu, S, Chen, P, Jiang, Y, Sun, X, Tao, Y, Hu, Y, Li, C, Wang, Q, Wang, Y, Chen, C.D, Shi, Y, and Zhang, X. 2015. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol 7(6):505–516.
Long, D, Zhao, A*, Xu, L, Lu, W, Guo, Q, Zhang, Y, and Xiang, Z. 2013. In vivo site-specific integration of transgene in silkworm via PhiC31 integrase-mediated cassette exchange. Insect Biochem Mol Biol43(11):997–1008.
Zhao, A*, Long, D, Ma, S, Xu, L, Zhang, M, Dai, F, Xia, Q, Lu, C, and Xiang, Z*. 2012. Efficient strategies for changing the diapause character of silkworm eggs and for the germline transformation of diapause silkworm strains. Insect Science 19:172–182.
Xu, L, Zhao, A*, Long, D, Tan, B, and Xiang, Z. 2011. PhiC31 integrase mediates genome manipulation in higher eukaryotes. Sci Sericulture 37(3):159–171.