Kotaro Anan, M.D., Ph.D.

Kotaro Anan, M.D., Ph.D.
Postdoctoral fellow, Pospisilik Laboratory


Dr. Kotaro Anan earned an M.D. and a Ph.D. in philosophy in medical science from Kumamoto University. Dr. Anan’s work focuses on regulating metabolic diseases by manipulating the genome and how environmental factors affect the pathophysiology of metabolic diseases. His work led him to be a senior resident in pediatrics at Kumamoto University Hospital, before going on to do a clinical fellowship and a research fellowship. In 2019, he joined the laboratory of Dr. Andrew Pospisilik at Van Andel Institute as a postdoctoral fellow.

Current research focus

Individual phenotypes can vary even in isogenic animal models. I have an interest in how this polyphenism can influence the development of metabolic diseases. I investigate epigenetic mechanisms of polyphenism and how to prevent or modulate the course of the diseases.

Education & Training

Ph.D. in philosophy in medical science, Kumamoto University (Advisor: Professor Mitsuyoshi Nakao)
Thesis: LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation

M.D., Kumamoto University School of Medicine


To view a list of selected publications click below.

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Takase R, Hino S, Nagaoka K, Anan K, Kohrogi K, Araki H, Hino Y, Sakamoto A, Nicholson TB, Chen T, Nakao M. 2019. Lysine-specific demethylase-2 is distinctively involved in brown and beige adipogenic differentiation. FASEB J 33(4):5300–5311. 

Anan K, Hino S, Shimizu N, Sakamoto A, Nagaoka K, Takase R, Kohrogi K, Araki H, Hino Y, Usuki S, Oki S, Tanaka H, Nakamura K, Endo F, Nakao M. 2018. LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation. Nucleic Acids Res 46: 5441–5454.

Sakamoto A, Hino S, Nagaoka K, Anan K, Takase R, Matsumori H, Ojima H, Kanai Y, Arita K, Nakao M. 2015. Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells. Cancer Res 75:1445–1456.

Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y, Nakao M. 2015. Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells. Mol Cell Biol 35:1068–1080.

Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K, Nakao M. 2012. FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun 3:758.