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Kevin A. Maupin, Ph.D.

Kevin A. Maupin, Ph.D.
Postdoctoral fellow, Haab Laboratory

Biography

Dr. Kevin Maupin earned his B.S. in cellular and molecular biology from Grand Valley State University and his Ph.D. in cellular and molecular genetics from Van Andel Institute Graduate School. His graduate work focused on designing and conducting experiments to analyze the role of galectin-3 in osteoblast and osteoclast differentiation, growth factor signaling, and metabolism, along with other bone cancer research and mouse modeling. Previously, he worked as an assistant research technician at Van Andel Institute in immunodiagnostics, including analyzing microarrays on human biological samples. In 2019, he joined the laboratory of Dr. Brian Haab as a postdoctoral fellow.

 

Current research focus

Glycosylation is the post-translational modification of proteins or lipids by the addition of various monosaccharides into larger polysaccharides known as “glycans.” The composition and structure of glycans are important for protein/lipid stability and function, thereby altering cell signaling. Glycan structures are frequently altered in disease states, particularly cancer. Dr. Maupin’s work involves understanding how glycan structures change during the progression of pancreatic cancer, whether these changes have functional consequences, as well as whether particular glycans can be used as biomarkers for improving cancer detection, patient stratification, and monitoring therapeutic response.

Education & Training

Postdoctoral fellow, Indiana University School of Medicine (Mentors: Dr. Melissa Kacena and Dr. Angela Bruzzaniti
Projects: 1. Altered growth factor signaling in bone cells aboard the International Space Station (PI: Dr. Melissa Kacena in collaboration with CASIS/NASA and U.S. Army) (2019); 2. Megakaryocyte regulation of bone mass and fracture healing (2017–2018); 3. Effects of microgravity on skeletal maturation in male mice (PI: Dr. Melissa Kacena in collaboration with CASIS/NASA and U.S. Army) (2017)

Ph.D. in cellular and molecular genetics, Van Andel Institute Graduate School (Advisor: Dr. Bart Williams)
Thesis: Loss of galectin-3 prevents cortical bone loss due to aging and gonadectomy

B.S. in cellular and molecular biology, Grand Valley State University

B.A. in psychology, Butler University (Indiana)

Awards & External Funding

NRSA Institutional Postdoctoral Training Grant/T32 (Indiana University School of Medicine) (2017 and 2018)

Young Investigator Travel Award, American Society for Bone and Mineral Research (2017)

Young Investigator Award, American Society for Bone and Mineral Research (2015)

Conference Travel Award, Society for Glycobiology (2015)

Idema Travel Award, Van Andel Institute Graduate School (2014)

Conference Travel Award, Society for Glycobiology (2013)

Most Outstanding Graduating Cellular and Molecular Biology Student, Grand Valley State University (2010)

Academic and Professional Enrichment Fund Recipient, Grand Valley State University (2010)

Academic Conference Travel Awards, Grand Valley State University (2010 and 2009)

Student Summer Scholarship, Grand Valley State University (2008)

Publications

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Maupin KA, Weaver K, Bergsma A, Christie C, Zhong ZA, Yang T, Williams BO. 2018. Enhanced cortical bone expansion in Lgals3-deficient mice during aging. Bone Res 6(7).

West MB, Partyka K, Feasley CL, Maupin KA, Goppallawa I, West CM, Haab BB, Hanigan MH. 2014. Detection of distinct glycosylation patterns on human gamma-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology. BMC Biotech 14:101.

Cao Z*, Maupin K*, Curnutte B, Fallon BP, Feasley CL, Brouhard E, Kwon R, West CM, Cunningham J, Brand RE, Castelli P, Crippa S, Feng Z, Allen P, Simeone DM, Haab BB. 2013. Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from non-mucinous pancreatic cysts. Mol Cell Proteomics 12(10): 2724–2734.
*Equal contributions

Fallon BP, Curnutte B, Maupin KA, Partyka K, Choi S, Brand RE, Langmead CJ, Tembe W, Haab BB. 2013. The Marker State Space (MSS) Method for classifying clinical samples. PLoS ONE 8(6):e65905.

McWilliam HEG, Driguez P, Piedrafita D, Maupin KA, Haab BB, McManus DP, Meeusen ENT. 2013. The developing and migrating stages of schistosome worms elicit distinct immune responses in different tissue regions. Immunol Cell Biol 91(7):477–485.

Partyka K, Maupin KA, Brand RE, Haab BB. 2012. Diverse monoclonal antibodies against the CA 19-9 antigen show variation in binding specificity with consequences for clinical interpretation. Proteomics 12(13):2212–2220.

Partyka K, McDonald M, Maupin KA, Brand R, Kwon R, Simeone DM, Allen P, Haab BB. 2012. Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification. J Proteome Res 11(5):2904–2911.

Maupin KA, Liden D, Haab BB. 2012. The fine specificity of mannose-binding and galactose-binding lectins revealed using outlier motif analysis of glycan array data. Glycobiology 22(1):160–169.

Yue T, Partyka K, Maupin K A, Hurley M, Andrews P, Kaul K, Moser AJ, Zeh H, Brand R E, Haab BB. 2011. Identification of blood-protein carriers of the CA 19-9 antigen and characterization of prevalence in pancreatic diseases. Proteomics 11:3665–3674.

Yue T*, Maupin KA*, Fallon B, Li L, Partyka K, Anderson MA, Brenner DE, Kaul K, Zeh H, Moser AJ, Simeone DM, Feng Z, Brand RE, Haab BB. 2011. Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers. PLoS ONE 6(12): e29180.
*Equal contributions

Maupin KA, Sinha A, Eugster E, Miller J, Ross J, Paulino V, Keshamouni VG, Tran N, Berens M, Webb C, Haab BB. 2010. Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems. PLoS ONE 5(9):e13002.