Dr. Hrit earned his B.S. in biochemistry from the University of Michigan, and his Ph.D. in biochemistry and molecular biology from University of California. His graduate work focused on the investigation of functional and physical interactions between enzymes OGT and TET1 in mammalian cells and implications in epigenetics, gene transcription and stem cell maintenance. He has received several awards and honors, including being an invited speaker for the international meeting, Protein O-GlcNAcylation in Health and Disease. In 2018, he joined the laboratory of Dr. Scott Rothbart at Van Andel Institute as a postdoctoral fellow.
Ph.D. in biochemistry and molecular biology, University of California, San Francisco (Ph.D. Advisor: Dr. Barbara Panning)
Thesis: Investigating the OGT-TET interaction in vitro and in mouse embryonic stem cells
B.S. in biochemistry, University of Michigan
Invited speaker, Protein O-GlcNAcylation in Health and Disease (2016)
Invited speaker, Briefings in Biotechnology course at City College San Francisco (2016)
California Institute for Regenerative Medicine Predoctoral Fellowship (TG2-01153) (2014)
NSF Graduate Research Fellowship Program Honorable Mention (2014)
To view a list of selected publications click below.
Hrit J, Goodrich L, Li C, Wang BA, Nie J, Cui X, Martin EA, Simental E, Fernandez J, Liu MY, Nery JR, Castanon R, Kohli RM, Tretyakova N, He C, Ecker JR, Goll M, Panning B. 2018. OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development. eLife.
Hrit J, Raynard N, Van Etten J, Petterson A, Sankar K, Goldstrohm A. 2014. In vitro analysis of RNA degradation catalyzed by deadenylase enzymes. Method Mol Biol 1125:325–339.
Van Etten J, Schagat T, Hrit J, Weidmann C, Brumbaugh J, Coon J, Goldstrohm AC. 2012. Human pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs. J Biol Chem 287:36370–36383.