Dr. Huadie Liu earned her B.S. in bioengineering from Hunan Agricultural University and her Ph.D. in genetics from Central South University in China. Her graduate work focused on how SUMOylation affects mesenchymal stem cell (MSC) differentiation. In 2015, while working on her thesis research, she joined Van Andel Institute as a guest student. In 2019, she joined the laboratory of Dr. Tao Yang at the Institute as a postdoctoral fellow.
Studying the role of epigenetic and sumoylation regulators in skeleton development and skeletal stem cell homeostasis.
Ph.D. in genetics, Central South University in China (Advisor: Dr. Jia-Da Li)
Thesis: Studies on the functions of Ginkgolic Acid, a sumoylation inhibitor, in the differentiation of mouse bone marrow stromal cells
B.S. in bioengineering, Hunan Agricultural University in China
To view a list of selected publications click below.
Li F, Li D, Liu H, Cao B, Jiang F, Chen DN, Li JD. 2019. RNF216 regulates the migration of immortalized GnRH neurons by suppressing Beclin1-mediated autophagy. Front Endocrinol (Lausanne) 10:12.
Di L, Li J, Liu H, Foxa G, Weaver K, Li J, Williams BO, Yang T. 2018. LRP1 suppresses bone resorption in mice by inhibiting the RANKL-stimulated NFkB and p38 pathway during osteoclastogenesis. J Bone Miner Res 33(10):1773–1717.
L Ji, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T. 2018. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nature Commun 9(1):143.
Liu H, Li J, Lu D, Li J, Liu M, He Y, Williams BO, Li J, Yang T. 2018. Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cells. Sci Rep 8(1):2545.
Li J, Lu D, Liu H, Williams BO, Overbeek PA, Lee B, Zheng L, Yang T. 2017. Sclt1-deficiency causes cystic kidney by activating ERK and STAT3 signaling. Hum Mol Genet 26(15):2949–2960.
Song J, Liu X, Li J, Liu H, Peng Z, Liu Y, Mei L, He C, Cai X, Chen H, Vleminckx K, Feng Y. 2017. Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4. Int J Clin Exp Med 10(4):6631–6639.
Zhang S, Zhang J, Deng Z, Liu H, Mao W, Jiang F, Xia Z, Li JD. 2016. Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells. Oncotarget 7(40).
Song J, Li J, Liu H, Liu W, Feng Y, Zhou XT, Lia JD. 2016. Snapin interacts with G-protein coupled receptor PKR2. Biochem Biophys Res Commun 469(3):501–506.
Chen DN, Ma YT, Liu H, Zhou QY, Li JD. 2014. Functional rescue of Kallmann Syndrome-associated PKR2 receptor mutants deficient in trafficking. J Biol Chem 289(22):15518–15526.
Yin W, Liu H, Peng Z, Chen D, Li J, Li JD. 2014. Mechanisms that underlie the internalization and extracellular signal regulated kinase 1/2 activation by PKR2 receptor. Cell Signal 26(5):1118–1124.