Dr. Hua Li earned a B.S. in food science and technology from Jiangnan University, followed by an M.S. in biochemistry and molecular biology from Sichuan University and a Ph.D. in biochemistry and molecular biology from Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. As a student and later as a postdoctoral fellow at Guangzhou Medical University, his work focused on structural studies of several pathogens, including poliovirus and dengue virus. In 2017, he joined the lab of Dr. Huilin Li at Van Andel Institute as a postdoctoral fellow.
Dr. Li uses cryo-EM, biophysics and biochemistry to study epigenetic mechanisms and ion channels related to disease.
Ph.D. in biochemistry and molecular biology, Guangzhou Institutes of Biomedicine and Health (Adviser: Dr. Jinsong Liu)
Thesis: Structural studies on the active conformation of DENV2 NS2B-NS3 protease and amiglycosyl transferase
M.S. in biochemistry and molecular biology, Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University
B.S. in food science and technology, School of Food Science and Technology, Jiangnan University
Postdoctoral fellowship, Sino-French Hoffmann Institute, Guangzhou Medical University (Mentor: Dr. Tao Peng)
Zhu L, Yang J, Li H, Sun H, Liu J*, Wang J*. 2015. Conformational change study of dengue virus NS2B-NS3 protease using 19F NMR spectroscopy. Biochem Biophys Res Commun 461(4):677–680.
Li H, Zhu L, Hou S, Yang J, Wang J*, Liu J*. 2014. An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease. FEBS Lett 588(17): 2794–2799.
Li H, Li LF, Su XD, Zhao X*, Liang YH*. 2007. Crystallization and preliminary X-ray crystallographic studies of SMU.134 protein from caries pathogen Streptococcus mutans. Protein Pept Lett 14(5): 503–504.
Bi Y, Zhu L, Li H, Wu B, Liu J*, Wang J*. 2013. Backbone 1H, 13C and 15N resonance assignments of dengue virus NS2B-NS3p in complex with aprotinin. Biomolecular NMR Assignments 7(2): 137–139.
Sun Q, Yao Y, Liu C, Li H, Yao H, Xue X, Liu J, Tu Z*, Jiang S*. 2013. Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry. Bioorg Med Chem Lett 23(11): 3295–3299.
Li X, Tu Z, Li H, Liu C, Li Z, Sun Q, Yao Y, Liu J, Jiang S*. 2012. Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry. ACS Med Chem Lett 4(1): 132–136.
Xu S, Li H, Shao X, Fan C, Ericksen B, Liu J, Chi C*, Wang C*. 2012. Critical effect of peptide cyclization on the potency of peptide inhibitors against dengue virus NS2B-NS3 protease. J Med Chem 55(15): 6881–6887.