Dr. Hongwen Xuan earned his B.S. in biotechnology at Northeast Agricultural University, China, and his Ph.D. in computational biology from the Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB). His graduate work focused on epigenetics and epigenomics, especially histone modifications, as well as the aging process and healthy aging. Along with his other research work, he is skilled in molecular and cell biology, as well as several computational biology methods. He is now a postdoctoral fellow in the laboratory of Dr. Xiaobing Shi at Van Andel Research Institute.
Cells mainly rely on “reader” proteins to interpret epigenetic information. The BAH domain is one type of histone methylation reader cross all eukaryotes. However, the targets and function of this domain in mammalian proteins reamins largely unknown. The BAH domain containing the protein ASH1L is a member of the trithorax group of transcriptional activators, and its H3K36 methyltranferase activity plays important role in development and cancer. Dr. Xuan is investigating the recognized targets of BAH domain on ASH1L and its relevant biological function.
Ph.D. in computational biology, University of Chinese Academy of Sciences (Advisor: Professors Jing-Dong and Jackie Han)
Thesis: Regulation of H3K27ac and H3K9me3 on aging process
B.S. in biotechnology, Northeast Agricultural University, China
Merit student of University of Chinese Academy of Sciences (2017–2018)
Merit student of University of Chinese Academy of Sciences (2016–2017)
International Max Planck Research Schools Scholarship, University of Chinese Academy of Sciences (2012–2013)
Merit student of University of Chinese Academy of Sciences
Excellent student cadre of University of Chinese Academy of Sciences
The third award comprehensive quality scholarship of university, Northeast Agricultural University (2008–2009)
To view a list of selected publications click below.
Cheng H, Xuan H, Green CD, Han Y, Sun N, Shen H, McDermott J, Bennett D, Lan F, Han JJ. 2018. Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation. Proc Natl Acad Sci U S A 201800656.
Dou X, Xuan H, Mu Y, Han JJ. 2017. Epigenetic regulation in aging process. Chinese Bulletin Life Sci 29:1052–1065.