616.234.5000

Hongkuan Wang, Ph.D.

Hongkuan Wang, Ph.D.
Postdoctoral fellow, Shi Laboratory
616.234.5854

Biography

Dr. Hongkuan Wang earned his B.S. in biological sciences from Henan Normal University and his Ph.D. in biochemistry and molecular biology from Fudan University. His graduate work focused on screening the novel meiotic genes and studying the function of the cohesin loader SCC2 in Arabidopsis meiosis. Dr. Wang is skilled in molecular biology, biochemistry and cytobiology (e.g., FISH and immunofluorescence). In 2019, he joined the laboratory of Dr. Xiaobing Shi at Van Andel Research Institute as a postdoctoral fellow.

 

Current research focus

Epigenetics plays important roles in maintenance of tissue-specific gene expression, and its dysregulation can lead to cancer development and progression in humans. To investigate the mechanism underlying how epigenetics changes the accessibility of chromatin to transcriptional 
regulation, we are working to identify the novel readers (recognizing histone or DNA modifications) participating this process. We also are screening the inhibitors of those epigenetic readers that can be applied to cure cancer.

Education & Training

Ph.D. in biochemistry and molecular biology, Fudan University  (Advisors: Professor Yingxiang Wang and Professor Gregory P. Copenhaver)
Thesis:  Study on the role of SCC2 in meiosis and the effect of temperature on meiotic recombination in Arabidopsis

B.S. in biological sciences, Henan Normal University

Awards & External Funding

Roche Diagnostics Education Fund (2017)

Scholarship of Academic Excellence (2013–2016)

Publications

To view a list of selected publications click below.

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Modliszewski JL, Wang H, Albright AR, Lewis SM, Bennett AR, Huang J, Ma H, Wang Y, Copenhaver GP. 2018. Elevated temperature increases meiotic crossover frequency via the interfering (Type I) pathway in Arabidopsis thaliana. PLoS Genet 14(5):e1007384.

Wang C, Huang J, Zhang J, Wang H, Han Y, Copenhaver GP, Ma H, Wang Y. 2019. The largest subunit of DNA polymerase delta is required for normal formation of meiotic Type I crossovers. Plant Physiol 179:1–14.

Wang J, Niu B, Huang J, Wang H, Yang X, Dong A, Makaroff C, Ma H, Wang Y. 2016. The PHD finger protein MMD1/DUET ensures the progression of male meiotic chromosome condensation and directly regulates the expression of the condensin gene CAP-D3. Plant Cell 28(8):1894–1909.