Dr. H. Diessel Duan earned his B.S in chemical engineering from Jiangnan University and his Ph.D. in biochemistry from Auburn University. His graduate work focused on catalase-peroxidase (KatG), a key enzyme for bacterial pathogens to survive oxidative damage from host immune responses. He went on to study flavin-based electron bifurcation, now regarded as the third mechanism of biological energy conservation. In 2020, he joined the lab of Dr. Huilin Li as a postdoctoral fellow.
Investigating the mechanisms of lipid transport across biological membranes by P4 ATPase machinery.
Postdoctoral fellow, University of Kentucky (Advisor: Dr. Anne-Frances Miller)
Ph.D. in biochemistry, Auburn University (Advisor: Dr. Doug Goodwin)
Thesis: KatG as a defense against hydrogen peroxide toxicity: from a redundant C-terminal domain to the paradoxical synergy of two mutually antagonistic activities
B.S. in chemical engineering, Jiangnan University (Wuxi, China)
To view a list of selected publications click below.
Duan HD, Mohamed-Raseek N., Miller A-F. 2020. Spectroscopic evidence for direct flavin-flavin contact in a bifurcating electron transfer flavoprotein. J Biol Chem 295:12618–12634.
Mohamed-Raseek N, Duan HD, Hildebrandt P, Mroginski MA, Miller A-F. 2019. Spectroscopic, thermodynamic and computational evidence of the locations of the FADs in the nitrogen fixationassociated electron transfer flavoprotein. Chem Sci 10:7762–7772.
Duan HD, Lubner CE, Tokmina-Lukaszewska M, Gauss GH, Bothner B, King PW, Peters JW, Miller A-F. 2018. Distinct properties underlie flavin-based electron bifurcation in a novel electron transfer flavoprotein FixAB from Rhodopseudomonas palustris. J Biol Chem 293:4688–4701.
Ledbetter RN, Garcia Costas AM, Lubner CE, Mulder DW, Tokmina-Lukaszewska M, Artz JH, Patterson A, Magnuson TS, Jay ZJ, Duan HD, Miller J, Plunkett MH, Hoben JP, Barney BM, Carlson RP, Miller A-F, Bothner B, King PW, Peters JW, Seefeldt LC. 2017. The electron bifurcating FixABCX protein complex from Azotobacter vinelandii: generation of low-potential reducing equivalents for nitrogenase catalysis. Biochemistry 56:4177–4190.