616.234.5000

H. Diessel Duan, Ph.D.

H. Diessel Duan, Ph.D.
Postdoctoral fellow, Huilin Li Laboratory
616.234.5289

Biography

Dr. H. Diessel Duan earned his B.S in chemical engineering from Jiangnan University and his Ph.D. in biochemistry from Auburn University. His graduate work focused on catalase-peroxidase (KatG), a key enzyme for bacterial pathogens to survive oxidative damage from host immune responses. He went on to study flavin-based electron bifurcation, now regarded as the third mechanism of biological energy conservation. In 2020, he joined the lab of Dr. Huilin Li as a postdoctoral fellow.

 

Current research focus

Investigating the mechanisms of lipid transport across biological membranes by P4 ATPase machinery.

Education & Training

Postdoctoral fellow, University of Kentucky (Advisor: Dr. Anne-Frances Miller)

Ph.D. in biochemistry, Auburn University (Advisor: Dr. Doug Goodwin)
Thesis: KatG as a defense against hydrogen peroxide toxicity: from a redundant C-terminal domain to the paradoxical synergy of two mutually antagonistic activities

B.S. in chemical engineering, Jiangnan University (Wuxi, China)

Publications

To view a list of selected publications click below.

Read More

Duan HD, Mohamed-Raseek N., Miller A-F. 2020. Spectroscopic evidence for direct flavin-flavin contact in a bifurcating electron transfer flavoprotein.  J Biol Chem 295:12618–12634.

Mohamed-Raseek N, Duan HD, Hildebrandt P, Mroginski MA, Miller A-F. 2019. Spectroscopic, thermodynamic and computational evidence of the locations of the FADs in the nitrogen fixationassociated electron transfer flavoprotein. Chem Sci 10:7762–7772.

Duan HD, Lubner CE, Tokmina-Lukaszewska M, Gauss GH, Bothner B, King PW, Peters JW, Miller A-F. 2018. Distinct properties underlie flavin-based electron bifurcation in a novel electron transfer flavoprotein FixAB from Rhodopseudomonas palustris. J Biol Chem 293:4688–4701.

Ledbetter RN, Garcia Costas AM, Lubner CE, Mulder DW, Tokmina-Lukaszewska M, Artz JH, Patterson A, Magnuson TS, Jay ZJ, Duan HD, Miller J, Plunkett MH, Hoben JP, Barney BM, Carlson RP, Miller A-F, Bothner B, King PW, Peters JW, Seefeldt LC. 2017. The electron bifurcating FixABCX protein complex from Azotobacter vinelandii: generation of low-potential reducing equivalents for nitrogenase catalysis. Biochemistry 56:4177–4190.