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J. Eduardo Pérez Mojica, Ph.D.

J. Eduardo Pérez-Mojica, Ph.D.
Postdoctoral fellow, Lempradl Laboratory
Email Dr. Pérez-Mojica

Biography

Dr. Pérez Mojica earned his B.S. in nutrition from the Autonomous University of Querétaro, his M.S. in molecular biomedicine from the CINVESTAV and his Ph.D. in human development and health from the University of Southampton. His graduate work focused on investigating the effect that fatty acids have on DNA methylation and post-translational modifications of histones. Overall, his research interests lay in understanding how environmental factors induce epigenetic modifications, which in turn, may promote disease states. He has numerous technical lab skills, including fatty acid determination by gas chromatography, reverse transcription (RT)-PCR, pyrosequencing, chromatin immunoprecipitation, transfection of cells, luciferase reporter assays, and more. In 2019, he joined the laboratory of Dr. Heidi Lempradl at Van Andel Institute as a postdoctoral fellow.

 

Current research focus

There is evidence that paternal environment has an effect on the next generations. However, it is still unknown how a paternal intergenerational signal leads to a specific, stable phenotype in offspring. In order to unravel such mechanisms, I will build upon our previously published Drosophila model of intergenerational metabolic reprograming (IGMR). Leveraging powerful Drosophila genetics and state-of-the-art genomic tools, the current project aims to elucidate how a paternal signal translates into a specific offspring phenotype. Due to the high conservation of metabolic and epigenetic pathways between Drosophila and mammals, this work will have profound implications in the field of intergenerational inheritance.

Education & Training

Ph.D. in human development and health,  University of Southampton (UK) (Advisor: Prof. Graham Burdge, Prof. Karen Lillycrop, Prof. Philip Calder and Prof. Cyrus Cooper)

Thesis: Investigation of the mechanisms underlying the effect of oleic acid and docosahexaenoic acid on DNA methylation in Jurkat cells

M.S. in molecular biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV) (Mexico) (Advisor: Dr. Gertrud Lund and Dr. Rosaura Hernández Rivas)
Thesis: DNA methylation changes in blood leukocytes in fasting and postprandial state in men

B.S. in nutrition, Autonomous University of Querétaro (Mexico)

Awards & External Funding

2014: Fellowship. Council for Science and Technology of Querétaro (CONCyTEQ), Mexico

2012: Fellowship. The National Council for Science and Technology (CONACyT), Mexico

Publications

To view a list of selected publications click below.

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Sibbons CM, Irvine NA, Pérez-Mojica JE, Calder PC, LillycropKA, Fielding BA, Burdge GC. 2018. Polyunsaturated fatty acid biosynthesis involving Δ8 desaturation and differential DNA methylation of FADS2 regulates proliferation of human peripheral blood mononuclear cells. Front Immuno 9:432.

de la Rocha C*, Pérez-Mojica JE*, León SZ*, Cervantes-Paz B, Tristán-Flores FE, Rodriguez-Rios D, Molina-Torres J, Ramirez-Chavez E, Alvarado-Caudillo Y, Carmona FJ, Esteller M, Hernandez-Rivas R, Wrobel K, Wrobel K, Zaina S, Lund G. 2016. Associations between whole peripheral blood fatty acids and DNA methylation in humans. Sci Rep 6:25867.

Poster/oral presentations

2018

13th congress of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)

Las Vegas, Nevada, USA

Oral presentation

2017

7th congress Epigenomics of Common Diseases

Wellcome Genome Campus, Cambridgeshire, UK

Poster display

2017

Southampton Medical and Health Research Conference

Southampton General Hospital, Southampton, UK

Poster display

2014

XIV International Meeting of Medical Sciences

Polyforum, León, Guanajuato, Mexico

Oral presentation