616.234.5000

Anne Drougard, Ph.D.

Anne Drougard, Ph.D.
Postdoctoral fellow, Pospisilik Laboratory
616.234.5882

Biography

Dr. Anne Drougard earned her B.S. in cell biology and physiology and her Ph.D. in neurophysiology from Toulouse III University. Her graduate studies focused on the hypothalamic control of the peripheral tissues. Her expertise lies in understanding the impact of hypothalamic changes into metabolic disease development, focusing on mitochondrial activity and oxidative stress within brain cells. In 2019, she joined the laboratory of Dr. Andrew Pospisilik at Van Andel Institute as a postdoctoral fellow.

 

Current research focus

Dr. Drougard’s work primarily focuses on analyzing the microglial cells changes upon a diet modification. She is investigating the early changes in genes expression, mitochondrial function, metabolomic differences related to the metabolic disruption. As part of her work, she will picture the molecular timeline into the type 2 diabetes development and try to reverse it on pharmacological or genetic models.

As a secondary project, she also investigates if N-acetylaspartate is a key metabolite for adipose tissues leading to potential therapeutic target for metabolic diseases.

As a third project, she will also work on the epigenetic causes of Parkinson’s disease.

Education & Training

Postdoctoral fellowship,  Max Planck Institute of Immunobiology and Epigenetics (Advisor: Dr Andrew Pospisilik) (Marie Curie Fellowship)

Ph.D. in neurophysiology, Toulouse III University (Advisor: Professor Claude Knauf) (Ministerial Grant)
Thesis: Hypothalamic apelin is involved in the implementation of Type 2 diabetes via targeting the liver

B.S. in cell biology and physiology, Toulouse III University

Publications

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Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M. 2017. Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release control. Cell Metab 25(6):1390–1399.e6.

Tay TL, Mai D, Dautzenberg J, Fernández-Klett F, Lin G, Sagar, Datta M, Drougard A, Stempfl T, Ardura-Fabregat A, Staszewski O, Margineanu A, Sporbert A, Steinmetz LM, Pospisilik JA, Jung S, Priller J, Grün D, Ronneberger O, Prinz M. 2017. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat Neurosci 20(6):793–803.

Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C. 2017. Apelin targets gut contraction to control glucose metabolism via the brain. Gut 66(2):258–269.

Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C. 2016. Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice. Sci Rep 6:31849.

Villain H, Benkahoul A, Drougard A, Lafragette M, Muzotte E, Pech S, Bui E, Brunet A, Birmes P, Roullet P. 2016. Effects of propranolol, a β-noradrenergic antagonist, on memory consolidation and reconsolidation in mice. Front Behav Neurosci 10:49.

Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. 2016. Apelin controls fetal and neonatal glucose homeostasis and is altered by maternal undernutrition. Diabetes 65(3):554-60.

Boal F, Roumegoux J, Alfarano C, Timotin A, Calise D, Anesia R, Drougard A, Knauf C, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Valet P, Parini A, Kunduzova O. 2015. Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity. Sci Rep 5:16104.

Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis. Schneeberger M, Gómez-Valadés AG, Altirriba J, Sebastián D, Ramírez S, Garcia A, Esteban Y, Drougard A, Ferrés-Coy A, Bortolozzi A, Garcia-Roves PM, Jones JG, Manadas B, Zorzano A, Gomis R, Claret M. Cell Rep. 2015 Jul 21;12(3):361-70. doi: 10.1016/j.celrep.2015.06.041. Epub 2015 Jul 9.

Drougard A, Fournel A, Valet P, Knauf C. 2015. Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake. Front Neurosci 9:56.

Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF. 2014. The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation. EMBO Mol Med 6(10):1328–1346.

Arvanitis DN, Behar A, Drougard A, Roullet P, Davy A. 2014.Cortical abnormalities and non-spatial learning deficits in a mouse model of CranioFrontoNasal syndrome. PLoS One 9(2):e88325.

Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C. 2014. Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes. Antioxid Redox Signal 20(4):557–573.

Butruille L, Drougard A, Knauf C, Moitrot E, Valet P, Storme L, Deruelle P, Lesage J. 2013. The apelinergic system: sexual dimorphism and tissue-specific modulations by obesity and insulin resistance in female mice. Peptides 46:94–101.

Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, Le Gonidec S, Moulédous L, Frances B, Leclercq I, Llorens-Cortes C, Pospisilik JA, Delzenne NM, Valet P, Castan-Laurell I, Knauf C. 2011. Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice. Antioxid Redox Signal 15(6):1477–1496.