For the human body to function properly, it must have the right amount of energy and resources in the right place at the right time. That’s the role of metabolism, a vast array of chemical reactions that power every biological process, from regulating appetite to ensuring that the immune system can continue to fight off invaders like illness-causing viruses and bacteria.
When energy production or distribution breaks down, the results can be catastrophic — diseases such as cancer, Parkinson’s and diabetes are all known to have varying degrees of metabolic involvement. By rigorously studying metabolism and how it is impacted by nutrition and our own genetics, Van Andel Research Institute’s Metabolic and Nutritional Programming team aims to develop scientifically driven strategies for improving health through earlier and improved prediction, prevention, diagnosis and treatment of disease.
Saibil SD*, St. Paul *, Laister RC, Garcia-Batres CR, Israni-Winger K, Elford AR, Grimshaw N, Robert-Tissot C, Roy DG, Jones RG, Nguyen LT, Ohashi PS. 2019. Activation of peroxisome proliferator activated receptors α and δ synergizes with inflammatory signals to enhance adoptive cell therapy. Cancer Res 79(3):445–451.
Klamer Z, Hsueh P, Ayala-Talavera D, Haab BB. 2019. Deciphering protein glycosylation by computational integration of on-chip profiling, glycan-array data, and mass spectrometry. Mol Cell Proteomics 18(1):28-40.
Staal B*, Liu Y*, Barnett D*, Hsueh P, Zonglin H, Gao C, Partyka K, Hurd MW, Singhi AD, Drake RR, Huang Y, Maitra A, Brand RE, Haab BB. 2019. The sTRA plasma biomarker: Blinded validation of improved accuracy over CA19-9 in pancreatic cancer diagnosis. Clin Cancer Res.
Guak H, Al Habyan S, Ma EH, Aldossary H, Al-Masri M, Won SY, Ting T, Fixman ED, Jones RG, McCaffrey LM, Krawczyk CM. 2018. Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration. Nat Commun 9(1):2563.
Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Terperino R, Enders L, Selveraj M, Ruf M, Raja SJ, Xie H, Boenisch U, Orkin Sh, Lynn FC, Hoffman BG, Grün D, Vovouri T, Lempradl A, Pospisilik JA. 2018. The Polycomb-dependent epigenome controls b cell dysfunction, dedifferentiation and diabetes. Cell Metab 27(6):1294–1308.
Save the date for Epigenomics at VARI symposium and graduate student workshop
Mark your calendars for the 2019 Epigenomics at VARI intensive workshop for advanced graduate students, which will be held July 29–Aug. 2 at the Institute! Taught by internationally recognized epigenomics experts, Epigenomics at VARI gives gifted graduate students an intense overview of the latest innovative methodology and its applications across several fields including cancer and neurodegenerative disease research. The application period opens March 1 and closes May 1. Learn more here.
At the start of the workshop, The Institute will host a one-day symposium on July 29. Registration opens in May. Learn more about the speakers here.
Looking for more information on the Institute’s scientific events? Join our email list here.
Save the date for the Midwest Metabolism Meeting!
This year’s Midwest Metabolism Meeting will be held Nov. 14 –15 at the Institute. Stay tuned for more information!