Hot Papers

Read the latest research from our laboratories published in scientific journals.

Is the enzyme ACMSD a novel therapeutic target in Parkinson’s disease? 
Keerthi Thirtamara-Rajamani, Peipei Li, Martha L. Escobar Galvis, Viviane Labrie, Patrik Brundin and Lena Brundin 
2017 | Journal of Parkinson’s Disease 

Assembly and architecture of the Wnt/β-catenin signalosome at the membrane 
Zachary J. DeBruine, H. Eric Xu and Karsten Melcher 
In press | British Journal of Pharmacology 

Therapeutic approaches to target alpha-synuclein pathology 
Patrik Brundin, Kuldip D. Dave and Jeffrey H. Kordower 
In press | Experimental Neurology 

Photosensing and thermosensing by phytochrome B require both proximal and distal allosteric features within the dimeric photoreceptor 
E. Sethe Burgie, Adam N. Bussell, Shu-Hui Lye, Tong Wang, Weiming Hu, Katrice E. McLoughlin, Erin L. Weber, Huilin Li and Richard D. Vierstra 
2017 | Scientific Reports

Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model 
Yasunori Noguchi, Auanning Yuan, Lin Bai, Sarah Schneider, Gongpu Zhao, Bruce Stillman, Christian Speck and Huilin Li 
In press | Proceedings of the National Academy of Sciences U.S.A. 

DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood 
S.J. van Dijk, T.J. Peters, M. Buckley, J. Zhou, P.A. Jones, R.A. Gibson, M. Makrides, B.S. Muhlhausler, and P.L. Molloy. 
In press | International Journal of Obesity 

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain 
An Phu Tran Nguyen, Guillaume Daniel, Pamela Valdés, Md. Shariful Islam, Bernard L. Schneider and Darren J. Moore 
In press | Human Molecular Genetics 

Mining high-complexity motifs in glycans: a new language to uncover the fine specificities of lectins and glycosidases 
Zachary Klamer, Ben Staal, Anthony R. Prudden, Lin Liu, David F. Smith, Geert-Jan Boons and Brian Haab. 
In press | Analytical Chemistry

Simultaneous targeting of two distinct epitopes on MET effectively inhibits MET- and HGF-driven tumor growth by multiple mechanisms 
Michael M. Grandal, Serhiy Havrylov, Thomas Tuxen Poulsen, Klaus Koefoed, Anna Dahlman, Gunther R. Galler, Paolo Conrotto, Sara Collins, Karsten W. Eeriksen, Dafna Kaufman, George F. Vande Woude, Helle J. Jacobsen, Ivan D. Horak, Michael Kragh, Johan Lantto, Thomas Bouquin, Morag Park and Mikkel Wandahl Pedersen 
In press | Molecular Cancer Therapeutics 

Analysis of histone antibody specificity with peptide microarrays 
Evan M. Cornett, Bradley M. Dickson and Scott B. Rothbart 
2017 | Journal of Visualized Experiments 

Prying into the prion hypothesis for Parkinson’s disease 
Patrik Brundin and Ronald Melki 
2017 | Journal of Neuroscience 

The REMOTE-control system: a system for reversible and tunable control of endogenous gene expression in mice 
Kwang-Ho Lee, Shirley Oghamian, Jin-A Park, Liang Kang and Peter W. Laird 
In press | Nucleic Acids Research

Biological iron–sulfur storage in a thioferrate–protein nanoparticle
Brian J. Vaccaro, Sonya M. Clarkson, James F. Holden, Dong-Woo Lee, Chang-Hao Wu, Farris L Poole, II, Julien J.H. Cotelesage, Mark J. Hackett, Sahel Mohebbi, Jingchuan Sun, Huilin Li, Michael K. Johnson, Graham N. George, and Michael W.W. Adams 
2017 | Nature Communications

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites 
Yan Yan, Ting-Hai Xu, Kaleeckal G. Marikumar, Laurence J. Miller, Karsten Melcher, and H. Eric Xu 
2017 | Journal of Biological Chemistry 

Deletion of tumor suppressors adenomatous polyposis coli and Smad4 in murine luminalepithelial cells causes invasive prostate cancer and loss of androgen receptor expression
Kenneth C. Valkenburg, Angelo M. De Marzo, and Bart O. Williams 
In press | Oncotarget

A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript 
Patrick J. Grohar, John Glod, Cody J. Peer, Tristan M. Sissung, Fernanda I. Arnaldez, Lauren Long, William D. Figg, Patricia Whitcomb, Lee J. Helman and Brigitte C. Widemann 
2017 | Cancer Chemotherapy and Pharmacology 

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein 
Trevor Tyson, Megan Senchuk, Jason F. Cooper, Sonia George, Jeremy M. Van Raamsdonk and Patrik Brundin 
2017 | Scientific Reports