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Hot Papers

Read the latest research from our laboratories published in scientific journals.

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer 
Patrick S. Dischinger, Elizabeth A. Tovar, Curt J. Essenburg, Zachary B. Madaj, Eve E. Gardner, Megan E. Callaghan, Ashley N. Turner, Anil K. Challa, Tristan Kempston, Bryn Eagleson, Robert A. Kesterson, Roderick T. Bronson, Megan J. Bowman, Carrie R. Graveel and Matthew R. Steensma 
2018 | npj Breast Cancer 

Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1 
Robert M.Vaughan, Bradley M. Dickson, Matthew F. Whelihan, Andrea L. Johnstone, Evan M. Cornett, Marcus A. Cheek, Christine A. Ausherman, Martis W. Cowles, Zu-Wen Sun and Scott B. Rothbart 
2018 | Proceedings of the National Academy of Sciences U.S.A.  

Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells 
Minmin Liu, Stacey L. Thomas, Ashley K. DeWitt, Wanding Zhou, Zachary B. Madaj, Hitoshi Ohtani, Stephen B. Baylin, Gangning Liang and Peter A. Jones 
In press | Cancer Research 

Biobanks and the moral concerns of donors: a democratic deliberation 
Raymond G. De Vries, Kerry A. Ryan, Linda Gordon, Chris D. Krenz, Tom Tomlinson, Scott Jewell and Scott Y.H. Kim 
In press | Qualitative Health Research 

Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy 
Babita Madan, Mitchell J. McDonald, Gabrielle E. Foxa, Cassandra R. Diegel, Bart O. Williams and David M. Virshup 
2018 | Bone Research 

Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses 
Hitoshi Ohtani, Minmin Liu, Wanding Zhou, Gangning Liang and Peter A. Jones 
2018 | Genome Research 

SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions 
Wanding Zhou, Timothy J. Triche, Jr., Peter W. Laird and Hui Shen 
In press | Nucleic Acids Research

14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic alpha-synuclein 
Bing Wang, Rachel Underwood, Anjali Kamath, Colleen Britain, Michael B. McFerrin, Pamela J. McLean, Laura A. Volpicelli-Daley, Robert H. Whitaker, William J. Placzek, Katelyn Becker, Jiyan Ma and Talene A. Yacoubian 
In press | Journal of Neuroscience 

Novel common genetic susceptibility loci for colorectal cancer 
Stephanie L. Schmitt, Christopher K. Edlund, Frederick R. Schumacher, Jian Gong, Tabitha A. Harrison, Jeroen R. Huyghe, Chenxu Qu, Marilena Melas, David J. Van Den Berg, Hansong Wang, Stephanie Tring, . . ., Gerhard A. Coetzee, Michelle Cotterchio, . . ., Li Hsu, David V. Conti and Stephen B. Gruber 
In press | Journal of the National Cancer Institute

Molecular mechanism of GPCR-mediated arrestin activation 
Naomi R. Latorraca, Jason K. Wang, Brian Bauer, Raphael J.L. Townshend, Scott A. Hollingsworth, Julie E. Olivieri, H. Eric Xu, Martha E. Sommer and Ron O. Dror 
2018 | Nature

Nuclear PTEN localization contributes to DNA damage repair in endometrial cancer and could have a diagnostic benefit for therapeutic management of the disease 
Ananda Mukherjee, Amanda L. Patterson, Jitu W. George, Tyler J. Carpenter, Zachary B. Madaj, Galen Hostetter, John I. Risinger and Jose M. Teixeira 
In press | Molecular Cancer Therapeutics

Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis 
Alexis Bergsma, Sourik S. Ganguly, Daniel Dick, Bart O. Williams and Cindy K. Miranti 
In press | Bone

Integrated molecular characterization of testicular germ cell tumors
Hui Shen, Juliann Shih, Daniel P. Hollern, Linghua Wang, Reanne Bowlby, Satish K. Tickoo, Vésteinn Thorsson, Andrew J. Mungall, Yulia Newton, Apurva M. Hegde, Joshua Armenia, . . ., The Cancer Genome Atlas Research Network, Rehan Akbani, David A. Wheeler, Peter W. Laird, Katherine L. Nathanson, Victoria K. Cortessis, and Katherine A. Hoadley 
2018 | Cell Reports

Cryo-EM structure of human rhodopsin bound to an inhibitory G protein 
Yanyong Kang, Oleg Kuybeda, Parker W. De Waal, Somnath Mukherjee, Ned Van Eps, Przemyslaw Dutka, X. Edward Zhou, Alberto Bartesaghi, Satchal Erramilli, Takefumi Morizumi, Xin Gu, Yanting Yin, Ping Liu, Yi Jiang, Xing Meng, Gongpu Zhao, Karsten Melcher, Oliver P. Ernst, Anthony A. Kossiakoff, Sriram Subramanian, and H. Eric Xu 
2018 | Nature

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting
Erin T. Williams, Liliane Glauser, Elpida Tsika, Haisong Jiang, Shariful Islam, and Darren J. Moore 
In press | Human Molecular Genetics

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration 
Emmanuel Quansah, Wouter Peelaerts, J. William Langston, David K. Simon, Jerry Colca, and Patrik Brundin 
2018 | Molecular Neurodegeneration

Structure of the human lipid-gated cation channel TRPC3 
Chen Fan, Wooyoung Choi, Weinan Sun, Juan Du and Wei Lu 
2018 | eLife

Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson’s disease reveals distinct metabolic profiles 
Stewart F. Graham, Nolwen L. Rey, Ali Yilmaz, Preveen Kumar, Zachary Madaj, Michael Maddens, Ray O. Bahado-Singh, Katelyn Becker, Emily Schulz, Lindsay K. Meyerdirk, Jennifer A. Steiner, Jiyan Ma and Patrik Brundin 
In press | Journal of Proteome Research

Structure of an ancient respiratory system 
Hongjun Yu, Chang-Hao Wu, Gerrit J. Schut, Dominik K. Haja, Gongpu Zhao, John W. Peters, Michael W.W. Adams and Huilin Li 
In press | Cell

LRP1 suppresses bone resorption in mice by inhibiting the RANKL-stimulated NFκB and p38 pathways during osteoclastogenesis 
Di Lu, Jianshuang Li, Huadie Liu, Gabrielle E. Foxa, Kevin Weaver, Jie Li, Bart O. William and Tao Yang 
In press | Journal of Bone and Mineral Research

Defining driver DNA methylation changes in human cancer 
Gerd P. Pfeifer 
2018 | International Journal of Molecular Sciences

DNA methylation loss in late-replicating domains is linked to mitotic cell division 
Wanding Zhou, Huy Q. Dinh, Zachary Ramjan, Daniel J. Weisenberger, Charles M. Nicolet, Hui Shen, Peter W. Laird and Benjamin P. Berman 
2018 | Nature Genetics

Genomic status of MET potentiates sensitivity to MET and MEK inhibition in NF1-related peripheral nerve sheath tumors
Jacqueline D. Peacock, Matthew G. Pridgeon, Elizabeth A. Tover, Curt J. Essenburg, Megan J. Bowman, Zachary B. Madaj, Julie Koeman, Elissa A. Boguslawski, Jamie Grit, Rebecca D. Dodd, Vadim Khachaturov, Diana M. Cardona, Mark Chen, David G. Kirsch, Flavio Maina, Rosanna Dono, Mary E. Winn, Carrie R. Graveel and Matthew R. Steensma 
In press | Cancer Research

Prion infectivity is encoded exclusively within the structure of proteinase K–resistant fragments of synthetically generated recombinant PrPSc
Fei Wang, Xinhe Wang, Romany Abskharon and Jiyan Ma 
2018 | Acta Neuropathologica Communications

The atomic structure of a eukaryotic oligosaccharyltransferase complex 
Lin Bai, Tong Wang, Gongpu Zhao, Amanda Kovach and Huilin Li 
2018 | Nature

Detecting alpha synuclein seeding activity in formaldehyde-fixed MSA patient tissue by PMCA 
Katelyn Becker, Xinhe Wang, Kayla Vander Stel, Yaping Chu, Jeffrey Kordower and Jiyan Ma 
In press | Molecular Neurobiology