Hot Papers

Read the latest research from our laboratories published in scientific journals.

Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling 
Jianshuang Li, Di Lu, Huadie Liu, Bart O. Williams, Paul A. Overbeek, Brendan Lee, Ling Zheng and Tao Yang 
In press | Human Molecular Genetics 

Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity 
Fei Wang, Xinhe Wang, Christina D. Orrú, Bradley R. Groveman, Krystyna Surewicz, Romany Abskharon, Morikazu Imamura, Takashi Yokoyama, Yong-Sun Kim, Kayla J. Vander Stel, Kumar Sinniah, Suzette A. Priola, Witold K. Surewicz, Byron Caughey and Jiyan Ma 
2017 | PLoS Pathogens 

Exosomal microRNAs in breast cancer towards diagnostic and therapeutic applications 
Lorenzo F. Sempere, Jessica Keto and Muller Fabbri 
2017 | Cancers 

Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells 
Ranjani Lakshminarasimhan, Claudia Andreu-Vieyra, Kate Lawrenson, Christopher E. Duymich, Simon A. Gayther, Gangning Liang and Peter A. Jones 
2017 | Cancer Letters

Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein–coupled receptors 
Yanting Yin, Parker W. de Waal, Yuanzheng He, Li-Hua Zhao, Dehua Yang, Xiaoqing Cai, Yi Jiang, Karsten Melcher, Ming-Wei Wang and H. Eric Xu 
In press | Journal of Biological Chemistry 

The CA19-9 and sialyl-TRA antigens define separate subpopulations of pancreatic cancer cells 
Daniel Barnett, Ying Liu, Katie Partyka, Ying Huang, Huiyuan Tang, Galen Hostetter, Randall E. Brand, Aatur D. Singhi, Richard R. Drake and Brian B. Haab 
2017 | Scientific Reports

Exendin-4 treatment improves LPS-induced depressive-like behavior without affecting pro-inflammatory cytokines 
Filip Ventorp, Cecillie Bay-Richter, Analise Sauro Nagendra, Shorena Janelidze, Viktor Sjödahl Matsson, Jack Lipton, Ulrika Nordström, Åsa Westrin, Patrik Brundin and Lena Brundin 
2017 | Journal of Parkinson’s Disease

An intrinsic epigenetic barrier for functional axon regeneration 
Xi-Lan Weng, Ran An, Jessica Cassin, Jessica Joseph, Ruifa Mi, Chen Wang, Chun Zhong, Seung-Gi Jin, Gerd P. Pfeifer, Alfonso Bellacosa, Xinzhong Dong, Ahmet Hoke, Zhigang He, Hongjun Song and Guo-li Ming 
2017 | Neuron 

Wnt5a promotes frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization 
Zachary J. DeBruine, Jiyuan Ke, Kaleeckal G. Harikumar, Xin Gu, Peter Borowsky, Bart O. Williams, Wenqing Xu, Laurence J. Miller, H. Eric Xu and Karsten Melcher 
2017 | Genes and Development 

Comparison of breast cancer molecular features and survival by African and European ancestry in The Cancer Genome Atlas 
Dezheng Huo, Hai Hu, Suhn K Rhie, Eric R. Gamazon, Andrew D. Cherniack, Jianfang Liu, Toshio F. Yoshimatsu, Jason J. Pitt, Katherine A. Hoadley, Melissa Troester, Yuanbin Ru, Tara Lichtenberg, Lori A. Sturtz, Carl S. Shelley, Christopher C. Benz, Gordon B. Mills, Peter W. Laird, Craig D. Shriver, Charles M. Perou and Olufunmilayo I. Olopade 
In press | JAMA Oncology

Mycobacterium tuberculosis proteasomal ATPase Mpa has a β-grasp domain that hinders docking with the proteasome core protease
Wu, Yujie, Kuan Hu, Defeng Li, Lin Bai, Shaoqing Yang, Jordan B. Jastrab, Shuhao Xiao, Yonglin Hu, Susan Zhang, K. Heran Darwin, Tao Wang and Huilin Li
In press | Molecular Microbiology

Phosphorylation of TXNIP by AKT mediates acute influx of glucose in response to insulin
Althea N. Waldhart, Holly Dykstra, Anderson S. Peck, Elissa A. Boguslawski, Zachary B. Madaj, Jennifer Wen, Kelsey Veldkamp, Matthew Hollowell, Bin Zheng, Lewis C. Cantley, Timothy E. McGraw and Ning Wu
2017 | Cell Reports

DDK promotes tumor chemoresistance and survival via multiple pathways
Nanda Kumar Sasi, Arjun Bhutkar, Nathan J. Lanning, Jeffrey P. MacKeigan and Michael Weinreich
2017 | Neoplasia

Parkinson disease
Werner Poewe, Klaus Seppi, Caroline M. Tanner, Glenda M. Halliday, Patrik Brundin, Jens Volkmann, Anette-Eleonore Schrag and Anthony E. Lang
2017 | Nature Reviews Disease Primers

Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a Phase 2 consortium/Stand Up 2 Cancer study
Nilofer S. Azad, Anthony el-Khoueiry, Jun Yin, Ann L. Oberg, Patrick Flynn, Douglas Adkins, Anup Sharma, Daniel J. Weisenberger, Thomas Brown, Prakriti Medvari, Peter A. Jones, Hariharan Easwaran, Ihab Kamel, Nathan Bahary, George Kim, Joel Picus, Henry C. Pitot, Charles Erilichman, Ross Donehower, Hui Shen, Peter W. Laird, Richard Piekarz, Stephen Baylin and Nita Ahuja
2017 | Oncotarget

Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases
Yan-Na Chen, Xin Gu, X. Edward Zhou, Weidong Wang, Dandan Cheng, Yinghua Ge, Fei Yi, H. Eric Xu and Zhengbing Lv
2017 | Protein Science

Six autoantibodies associated with autoimmune encephalitis are not detectable in the cerebrospinal fluid of suicide attempters 
Johan Fernström, Åsa Westrin, Cécile Grudet, Lil Träskman-Bendz, Lena Brundin, and Daniel Lindqvist
2017 | PLoS One