VAN ANDEL INSTITUTE
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Read the latest research from our laboratories published in scientific journals.
A highly sensitive non-radioactive activity assay for AMP-activated protein kinase (AMPK) Yan Yan, Xin Gu, H. Eric Xu and Karsten Melcher 2018 | Methods and Protocols
The ring-shaped hexameric helicases that function at DNA replication forks Michael E. O’Donnell and Huilin Li 2018 | Nature Structural & Molecular Biology
The College of American Pathologists Biorepository Accreditation Program: results from the first 5 years Shannon J. McCall, Philip A. Branton, Victoria M. Blanc, Sarah M. Dry, Julie M. Gastier-Forster, James H. Harrison, Scott D. Jewell, Rajesh C. Dash, Rebecca C. Obeng, Joan Rose, Dawna L. Mateski, Albi Liiubinskas, James A. Robb, Nilsa C. Ramirez and Kathi Shea. 2018 | Biopreservation and Biobanking
Loss of TGF-β signaling in osteoblasts increases basic-FGF and promotes prostate cancer bone metastasis Xiangqi Meng, Alexandra Vander Ark, Paul Daft, Erica Woodford, Jie Wang, Zachary Madaj and Xiaohong Li In press | Cancer Letters
Desumoylase SENP6 maintains osteochrondroprogenitor homeostasis by suppressing the p53 pathwayJianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T.H. Yeh, Bart O. Williams, Ling Zheng, and Tao Yang 2018 | Nature Communications
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2Emiliano Zamponi, Fiamma Buratti, Gabriel Cataldi, Hector Hugo Caicedo, Yuyu Song, Lisa M. Jungbauer, Mary J. LaDu, Mariano Bisbal, Alfredo Lorenzo, Jiyan Ma, Pablo R. Helguera, Gerardo A. Morfini, Scott T. Brady, and Gustavo F. Pigino 2017 | PLoS One
Genetic effects on gene expression across human tissues The GTEx Consortium 2017 | Nature
Comprehensive and integrated genomic characterization of adult soft tissue sarcomasThe Cancer Genome Atlas Research Network 2017 | Cell
Electron cryo-microscopy structure of a human TRPM4 channel Paige A. Winkler, Yihe Huang, Weinan Sun, Juan Du and Wei Lü 2017 | Nature
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activate lymphocytesRuda de Luna Almeida Santos, Lin Bai, Pradeep K. Singh, Naoka Murakami, Hao Fan, Wenhu Zhan, Yingrong Zhu, Xiuju Jiang, Kaiming Zhang, Jean Pierre Assker, Carl F. Nathan, Huilin Li, Jamil Azzi and Gang Lin 2017 | Nature Communications
The arginine methyltransferase PRMT6 regulates DNA methylation and contributes to global DNA hypomethylation in cancer Nicolas Veland, Swanand Hardikar, Yi Zhong, Sitaram Sayatri, Jiameng Dan, Brian D. Strahl, Scott B. Rothbart, Mark T. Bedford and Taiping Chen 2017 | Cell Reports
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term Nolwen L. Rey, Sonia George, Jennifer A. Steiner, Zachary Madaj, Kelvin C. Luk, John Q. Trojanowski, Virginia M.-Y. Lee and Patrik Brundin 2018 | Acta Neuropathologica
Is the enzyme ACMSD a novel therapeutic target in Parkinson’s disease? Keerthi Thirtamara-Rajamani, Peipei Li, Martha L. Escobar Galvis, Viviane Labrie, Patrik Brundin and Lena Brundin 2017 | Journal of Parkinson’s Disease
Assembly and architecture of the Wnt/β-catenin signalosome at the membrane Zachary J. DeBruine, H. Eric Xu and Karsten Melcher In press | British Journal of Pharmacology
Therapeutic approaches to target alpha-synuclein pathology Patrik Brundin, Kuldip D. Dave and Jeffrey H. Kordower In press | Experimental Neurology
Photosensing and thermosensing by phytochrome B require both proximal and distal allosteric features within the dimeric photoreceptor E. Sethe Burgie, Adam N. Bussell, Shu-Hui Lye, Tong Wang, Weiming Hu, Katrice E. McLoughlin, Erin L. Weber, Huilin Li and Richard D. Vierstra 2017 | Scientific Reports
Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model Yasunori Noguchi, Auanning Yuan, Lin Bai, Sarah Schneider, Gongpu Zhao, Bruce Stillman, Christian Speck and Huilin Li In press | Proceedings of the National Academy of Sciences U.S.A.