Hot Papers

Read the latest research from our laboratories published in scientific journals.

Osteoblast-specific deletion of Hprt2/Cdc73 results in high bone mass and increased bone turnover
Casey J. Droscha, Cassandra R. Diegel, Nicole J. Ethen, Travis A. Burgers, Mitchell J. McDonald, Kevin A. Maupin, Agni S. Naidu, PengFei Wang, Bin T. Teh, and Bart O. Williams
2017 | Bone

Parkinson’s disease-associated genetic variation is linked to quantitative expression of inflammatory genes
Steven Pierce and Gerhard A. Coetzee
2017 | PLoS One

Structural analysis of Mycobacterium tuberculosis homologues of the eukaryotic proteasome assembly chaperone 2 (PAC2)
Lin Bai, Jordan B. Jastrab, Marta Isasa, Kuan Hu, Hongjun Yu, Steven P. Gygi, K. Heran Darwin and Huilin Li
In press | Journal of Bacteriology

MET4 expression predicts poor prognosis of gastric cancers with Helicobacter pylori infection
Naoko Sakamoto, Hironori Tsujimoto, Risa Takahata, Brian Cao, Zhou Ping, Nozomi Ito, Hideyuki Shimazaki, Takashi Ichikura, Kazuo Hase, George F. Vande Woude and Nariyoshi Shinomiya
In press | Cancer Science

Nucleosome positioning and NDR structure at RNA polymerase III promoters
Alexandra Søgaard Helbo, Fides D. Lay, Peter A. Jones, Gangning Liang and Kirsten Grønbaek
2017 | Scientific Reports

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
Nolwen L. Rey, Daniel W. Wesson and Patrik Brundin
In press | Neurobiology of Disease

Epigenetic biomarkers for Parkinson’s disease: from diagnostics to therapeutics
Jennifer L. Jakubowski and Viviane Labrie
2017 | Journal of Parkinson’s Disease

Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes
Wanding Zhou, Peter W. Laird, and Hui Shen
2017 | Nucleic Acids Research

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation
Md. Shariful Islam and Darren J. Moore
2017 | Biochemical Society Transactions

Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro
Wei Yi, Jingjing Shi, Guanquan Zhao, X. Edward Zhou, Kelly Suino-Powell, Karsten Melcher and H. Eric Xu
2017 | Scientific Reports

epiG: Statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data
Martin Vincent, Kamilla Mundbjerg, Jakob Skou Pedersen, Gangning Liang, Peter A. Jones, Torben Falck Ørntoft, Karina Dalsgaard Sørensen and Carsten Wiuf.
2017 | Genome Biology

Structural insights into alternative splicing-mediated desensitization of jasmonate signaling
Feng Zhang, Jiyuan Ke, Li Zhang, Rongzhi Chen, Koichi Sugimoto, Gregg A. Howe, H. Eric Xu, Mingguo Zhou, Sheng Yang He and Karsten Melcher
2017 | Proceedings of the National Academy of Sciences U.S.A.

Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome
Edward Oh, Richie Jeremian, Gabriel Oh, Daniel Groot, Miki Susic, KwangHo Lee, Kelly Foy, Peter W. Laird, Arturas Petronis and Viviane Labrie
2017 | Scientific Reports

The OncoArray Consortium: a network for understanding the genetic architecture of common cancers
Christopher I. Amos, Joe Dennis, Zhaoming Wang, Jinyoung Byun, Fredrick R. Schumacher, Simon A. Gayther, Graham Casey, David J. Hunter, Thomas A. Sellers, Stephen B. Gruber, Alison M. Dunning, Kyriaki Michailidou, Laura Fachal, Kimberly Doheny, Amanda B. Spurdle, Yafang Li, Xiangjun Xiao, Jane Romm, Elizabeth Pugh, Gerhard A. Coetzee, Dennis J. Hazelett, Stig E. Bojesen, Charlisse Caga-Anan, Christopher A. Haiman, Ahsan Kamal, Craig Luccarini, Daniel Tessier, Daniel Vincent, François Bacot, David J. Van Den Berg, Stefanie Nelson, Stephen Demetriades, David E. Goldgar, Fergus J. Couch, Judith L. Forman, Graham G. Giles, David V. Conti, Heike Bickeböller, Angela Risch, Melanie Waldenberger, Irene Brüske-Hohlfeld, Belynda D. Hicks, Hua Ling, Lesley McGuffog, Andrew Lee, Karoline Kuchenbaecker, Penny Soucy, Judith Manz, Julie M. Cunningham, Katja Butterbach, Zsofia Kote-Jarai, Peter Kraft, Liesel FitzGerald, Sara Lindström, Marcia Adams, James D. McKay, Catherine M. Phelan, Sara Benlloch, Linda E. Kelemen, Paul Brennan, Marjorie Riggan, Tracy A. O’Mara, Hongbing Shen, Yongyong Shi, Deborah J. Thompson, Marc T. Goodman, Sune F. Nielsen, Andrew Berchuck, Sylvie Laboissiere, Stephanie L. Schmit, Tameka Shelford, Christopher K. Edlund, Jack A. Taylor, John K. Field, Sue K. Park, Kenneth Offit, Mads Thomassen, Rita Schmutzler, Laura Ottini, Rayjean J. Hung, Jonathan Marchini, Ali Amin Al Olama, Ulrike Peters, Rosalind A. Eeles, Michael F. Seldin, Elizabeth Gillanders, Daniela Seminara, Antonis C. Antoniou, Paul D.P. Pharoah, Georgia Chenevix-Trench, Stephen J. Chanock, Jacques Simard and Douglas F. Easton
2017 | Cancer, Epidemiology, Biomarkers & Prevention

Characterizing protein glycosylation through on-chip glycan modification and probing
Bryan S. Reatini, Elliot Ensink, Brian Liau, Jessica Y. Sinha, Thomas W. Powers, Katie Partyka, Marshall Bern, Randall E. Brand, Pauline M. Rudd, Doron Kletter, Richard Drake and Brian B. Haab
2016 | Analytical Chemistry