Hot Papers

Read the latest research from our laboratories published in scientific journals.

Mycobacterium tuberculosis proteasomal ATPase Mpa has a β-grasp domain that hinders docking with the proteasome core protease
Wu, Yujie, Kuan Hu, Defeng Li, Lin Bai, Shaoqing Yang, Jordan B. Jastrab, Shuhao Xiao, Yonglin Hu, Susan Zhang, K. Heran Darwin, Tao Wang and Huilin Li
In press | Molecular Microbiology

Phosphorylation of TXNIP by AKT mediates acute influx of glucose in response to insulin
Althea N. Waldhart, Holly Dykstra, Anderson S. Peck, Elissa A. Boguslawski, Zachary B. Madaj, Jennifer Wen, Kelsey Veldkamp, Matthew Hollowell, Bin Zheng, Lewis C. Cantley, Timothy E. McGraw and Ning Wu
2017 | Cell Reports

DDK promotes tumor chemoresistance and survival via multiple pathways
Nanda Kumar Sasi, Arjun Bhutkar, Nathan J. Lanning, Jeffrey P. MacKeigan and Michael Weinreich
2017 | Neoplasia

Parkinson disease
Werner Poewe, Klaus Seppi, Caroline M. Tanner, Glenda M. Halliday, Patrik Brundin, Jens Volkmann, Anette-Eleonore Schrag and Anthony E. Lang
2017 | Nature Reviews Disease Primers

Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a Phase 2 consortium/Stand Up 2 Cancer study
Nilofer S. Azad, Anthony el-Khoueiry, Jun Yin, Ann L. Oberg, Patrick Flynn, Douglas Adkins, Anup Sharma, Daniel J. Weisenberger, Thomas Brown, Prakriti Medvari, Peter A. Jones, Hariharan Easwaran, Ihab Kamel, Nathan Bahary, George Kim, Joel Picus, Henry C. Pitot, Charles Erilichman, Ross Donehower, Hui Shen, Peter W. Laird, Richard Piekarz, Stephen Baylin and Nita Ahuja
2017 | Oncotarget

Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases
Yan-Na Chen, Xin Gu, X. Edward Zhou, Weidong Wang, Dandan Cheng, Yinghua Ge, Fei Yi, H. Eric Xu and Zhengbing Lv
2017 | Protein Science

Six autoantibodies associated with autoimmune encephalitis are not detectable in the cerebrospinal fluid of suicide attempters 
Johan Fernström, Åsa Westrin, Cécile Grudet, Lil Träskman-Bendz, Lena Brundin, and Daniel Lindqvist
2017 | PLoS One

Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions
Erin K. Shanle, Stephen A. Shinsky, Joseph B. Bridgers, Narkhyun Bae, Cari Sagum, Krzysztof Krajewski, Scott B. Rothbart, Mark T. Bedford, and Brian D. Strahl 
2017 | Epigenetics and Chromatin

An immortalized human dorsal root ganglia cell line provides a novel context to study herpes simplex virus Type-1 latency and reactivation
Nikki M. Thellman, Carolyn Botting, Zachary Madaj, and Steven J. Triezenberg 
In press | Journal of Virology

Integrated molecular characterization of uterine carcinosarcoma
Andrew D. Cherniack, Hui Shen, Vonn Walter, Chip Stewart, Bradley A. Murray, Reanne Bowlby, Xin Hu, Shiyun Ling, Robert A. Soslow, Russell R. Broaddus, Rosemary E. Zuna, Gordon Robertson, Peter W. Laird, Raju Kucherlapati, Gordon B. Mills, The Cancer Genome Atlas Research Network, John N. Weinstein, Jiashan Zhang, Rehan Akbani, and Douglas A. Levine 
2017 | Cancer Cell

Osteoblast-specific deletion of Hprt2/Cdc73 results in high bone mass and increased bone turnover
Casey J. Droscha, Cassandra R. Diegel, Nicole J. Ethen, Travis A. Burgers, Mitchell J. McDonald, Kevin A. Maupin, Agni S. Naidu, PengFei Wang, Bin T. Teh, and Bart O. Williams
2017 | Bone

Parkinson’s disease-associated genetic variation is linked to quantitative expression of inflammatory genes
Steven Pierce and Gerhard A. Coetzee
2017 | PLoS One

Structural analysis of Mycobacterium tuberculosis homologues of the eukaryotic proteasome assembly chaperone 2 (PAC2)
Lin Bai, Jordan B. Jastrab, Marta Isasa, Kuan Hu, Hongjun Yu, Steven P. Gygi, K. Heran Darwin and Huilin Li
In press | Journal of Bacteriology

MET4 expression predicts poor prognosis of gastric cancers with Helicobacter pylori infection
Naoko Sakamoto, Hironori Tsujimoto, Risa Takahata, Brian Cao, Zhou Ping, Nozomi Ito, Hideyuki Shimazaki, Takashi Ichikura, Kazuo Hase, George F. Vande Woude and Nariyoshi Shinomiya
In press | Cancer Science

Nucleosome positioning and NDR structure at RNA polymerase III promoters
Alexandra Søgaard Helbo, Fides D. Lay, Peter A. Jones, Gangning Liang and Kirsten Grønbaek
2017 | Scientific Reports

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
Nolwen L. Rey, Daniel W. Wesson and Patrik Brundin
In press | Neurobiology of Disease

Epigenetic biomarkers for Parkinson’s disease: from diagnostics to therapeutics
Jennifer L. Jakubowski and Viviane Labrie
2017 | Journal of Parkinson’s Disease