Hot Papers

Read the latest research from our laboratories published in scientific journals.

Biological iron–sulfur storage in a thioferrate–protein nanoparticle
Brian J. Vaccaro, Sonya M. Clarkson, James F. Holden, Dong-Woo Lee, Chang-Hao Wu, Farris L Poole, II, Julien J.H. Cotelesage, Mark J. Hackett, Sahel Mohebbi, Jingchuan Sun, Huilin Li, Michael K. Johnson, Graham N. George, and Michael W.W. Adams 
2017 | Nature Communications

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites 
Yan Yan, Ting-Hai Xu, Kaleeckal G. Marikumar, Laurence J. Miller, Karsten Melcher, and H. Eric Xu 
2017 | Journal of Biological Chemistry 

Deletion of tumor suppressors adenomatous polyposis coli and Smad4 in murine luminalepithelial cells causes invasive prostate cancer and loss of androgen receptor expression
Kenneth C. Valkenburg, Angelo M. De Marzo, and Bart O. Williams 
In press | Oncotarget

A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript 
Patrick J. Grohar, John Glod, Cody J. Peer, Tristan M. Sissung, Fernanda I. Arnaldez, Lauren Long, William D. Figg, Patricia Whitcomb, Lee J. Helman and Brigitte C. Widemann 
2017 | Cancer Chemotherapy and Pharmacology 

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein 
Trevor Tyson, Megan Senchuk, Jason F. Cooper, Sonia George, Jeremy M. Van Raamsdonk and Patrik Brundin 
2017 | Scientific Reports 

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer 
Paz Polak, Jaegil Kim, Lior Z. Braunstein, Rosa Karlilc, Nicholas J. Haradhavala, Grace Tiao, Daniel Rosebrock, Dimitri Livitz, Kirsten Kübler, Kent W. Mouw, Atanas Kamburov, Yosef E. Maruvka, Ignaty Leshchiner, Eric S. Lander, Todd R. Golub, Aviad Zick, Alexandre Orthwein, Michael S. Lawrence, Rajbir N. Batra, Carlos Caldas, Daniel A. Haber, Peter W. Laird, Hui Shen, Leif W. Ellisen, Alan D. D’Andrea, Stephen J. Chanock, William D. Foulkes and Gad Getz 
In press | Nature Genetics 

Herpes simplex virus establishment, maintenance, and reactivation: in vitro modeling of latency 
Nikki M. Thellman and Steven J. Triezenberg 
2017 | Pathogens

Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling 
Jianshuang Li, Di Lu, Huadie Liu, Bart O. Williams, Paul A. Overbeek, Brendan Lee, Ling Zheng and Tao Yang 
In press | Human Molecular Genetics 

Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity 
Fei Wang, Xinhe Wang, Christina D. Orrú, Bradley R. Groveman, Krystyna Surewicz, Romany Abskharon, Morikazu Imamura, Takashi Yokoyama, Yong-Sun Kim, Kayla J. Vander Stel, Kumar Sinniah, Suzette A. Priola, Witold K. Surewicz, Byron Caughey and Jiyan Ma 
2017 | PLoS Pathogens 

Exosomal microRNAs in breast cancer towards diagnostic and therapeutic applications 
Lorenzo F. Sempere, Jessica Keto and Muller Fabbri 
2017 | Cancers 

Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells 
Ranjani Lakshminarasimhan, Claudia Andreu-Vieyra, Kate Lawrenson, Christopher E. Duymich, Simon A. Gayther, Gangning Liang and Peter A. Jones 
2017 | Cancer Letters

Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein–coupled receptors 
Yanting Yin, Parker W. de Waal, Yuanzheng He, Li-Hua Zhao, Dehua Yang, Xiaoqing Cai, Yi Jiang, Karsten Melcher, Ming-Wei Wang and H. Eric Xu 
In press | Journal of Biological Chemistry 

The CA19-9 and sialyl-TRA antigens define separate subpopulations of pancreatic cancer cells 
Daniel Barnett, Ying Liu, Katie Partyka, Ying Huang, Huiyuan Tang, Galen Hostetter, Randall E. Brand, Aatur D. Singhi, Richard R. Drake and Brian B. Haab 
2017 | Scientific Reports

Exendin-4 treatment improves LPS-induced depressive-like behavior without affecting pro-inflammatory cytokines 
Filip Ventorp, Cecillie Bay-Richter, Analise Sauro Nagendra, Shorena Janelidze, Viktor Sjödahl Matsson, Jack Lipton, Ulrika Nordström, Åsa Westrin, Patrik Brundin and Lena Brundin 
2017 | Journal of Parkinson’s Disease

An intrinsic epigenetic barrier for functional axon regeneration 
Xi-Lan Weng, Ran An, Jessica Cassin, Jessica Joseph, Ruifa Mi, Chen Wang, Chun Zhong, Seung-Gi Jin, Gerd P. Pfeifer, Alfonso Bellacosa, Xinzhong Dong, Ahmet Hoke, Zhigang He, Hongjun Song and Guo-li Ming 
2017 | Neuron 

Wnt5a promotes frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization 
Zachary J. DeBruine, Jiyuan Ke, Kaleeckal G. Harikumar, Xin Gu, Peter Borowsky, Bart O. Williams, Wenqing Xu, Laurence J. Miller, H. Eric Xu and Karsten Melcher 
2017 | Genes and Development 

Comparison of breast cancer molecular features and survival by African and European ancestry in The Cancer Genome Atlas 
Dezheng Huo, Hai Hu, Suhn K Rhie, Eric R. Gamazon, Andrew D. Cherniack, Jianfang Liu, Toshio F. Yoshimatsu, Jason J. Pitt, Katherine A. Hoadley, Melissa Troester, Yuanbin Ru, Tara Lichtenberg, Lori A. Sturtz, Carl S. Shelley, Christopher C. Benz, Gordon B. Mills, Peter W. Laird, Craig D. Shriver, Charles M. Perou and Olufunmilayo I. Olopade 
In press | JAMA Oncology