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Hot Papers

Read the latest research from our laboratories published in scientific journals.

Epigenetic biomarkers for Parkinson’s disease: from diagnostics to therapeutics
Jennifer L. Jakubowski and Viviane Labrie
2017 | Journal of Parkinson’s Disease

Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes
Wanding Zhou, Peter W. Laird, and Hui Shen
2017 | Nucleic Acids Research

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation
Md. Shariful Islam and Darren J. Moore
2017 | Biochemical Society Transactions

Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro
Wei Yi, Jingjing Shi, Guanquan Zhao, X. Edward Zhou, Kelly Suino-Powell, Karsten Melcher and H. Eric Xu
2017 | Scientific Reports

epiG: Statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data
Martin Vincent, Kamilla Mundbjerg, Jakob Skou Pedersen, Gangning Liang, Peter A. Jones, Torben Falck Ørntoft, Karina Dalsgaard Sørensen and Carsten Wiuf.
2017 | Genome Biology

Structural insights into alternative splicing-mediated desensitization of jasmonate signaling
Feng Zhang, Jiyuan Ke, Li Zhang, Rongzhi Chen, Koichi Sugimoto, Gregg A. Howe, H. Eric Xu, Mingguo Zhou, Sheng Yang He and Karsten Melcher
2017 | Proceedings of the National Academy of Sciences U.S.A.

Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome
Edward Oh, Richie Jeremian, Gabriel Oh, Daniel Groot, Miki Susic, KwangHo Lee, Kelly Foy, Peter W. Laird, Arturas Petronis and Viviane Labrie
2017 | Scientific Reports

The OncoArray Consortium: a network for understanding the genetic architecture of common cancers
Christopher I. Amos, Joe Dennis, Zhaoming Wang, Jinyoung Byun, Fredrick R. Schumacher, Simon A. Gayther, Graham Casey, David J. Hunter, Thomas A. Sellers, Stephen B. Gruber, Alison M. Dunning, Kyriaki Michailidou, Laura Fachal, Kimberly Doheny, Amanda B. Spurdle, Yafang Li, Xiangjun Xiao, Jane Romm, Elizabeth Pugh, Gerhard A. Coetzee, Dennis J. Hazelett, Stig E. Bojesen, Charlisse Caga-Anan, Christopher A. Haiman, Ahsan Kamal, Craig Luccarini, Daniel Tessier, Daniel Vincent, François Bacot, David J. Van Den Berg, Stefanie Nelson, Stephen Demetriades, David E. Goldgar, Fergus J. Couch, Judith L. Forman, Graham G. Giles, David V. Conti, Heike Bickeböller, Angela Risch, Melanie Waldenberger, Irene Brüske-Hohlfeld, Belynda D. Hicks, Hua Ling, Lesley McGuffog, Andrew Lee, Karoline Kuchenbaecker, Penny Soucy, Judith Manz, Julie M. Cunningham, Katja Butterbach, Zsofia Kote-Jarai, Peter Kraft, Liesel FitzGerald, Sara Lindström, Marcia Adams, James D. McKay, Catherine M. Phelan, Sara Benlloch, Linda E. Kelemen, Paul Brennan, Marjorie Riggan, Tracy A. O’Mara, Hongbing Shen, Yongyong Shi, Deborah J. Thompson, Marc T. Goodman, Sune F. Nielsen, Andrew Berchuck, Sylvie Laboissiere, Stephanie L. Schmit, Tameka Shelford, Christopher K. Edlund, Jack A. Taylor, John K. Field, Sue K. Park, Kenneth Offit, Mads Thomassen, Rita Schmutzler, Laura Ottini, Rayjean J. Hung, Jonathan Marchini, Ali Amin Al Olama, Ulrike Peters, Rosalind A. Eeles, Michael F. Seldin, Elizabeth Gillanders, Daniela Seminara, Antonis C. Antoniou, Paul D.P. Pharoah, Georgia Chenevix-Trench, Stephen J. Chanock, Jacques Simard and Douglas F. Easton
2017 | Cancer, Epidemiology, Biomarkers & Prevention

Characterizing protein glycosylation through on-chip glycan modification and probing
Bryan S. Reatini, Elliot Ensink, Brian Liau, Jessica Y. Sinha, Thomas W. Powers, Katie Partyka, Marshall Bern, Randall E. Brand, Pauline M. Rudd, Doron Kletter, Richard Drake and Brian B. Haab
2016 | Analytical Chemistry

Chromosome instability drives phenotypic switching to metastasis
ChongFeng Gao, Yanli Su, Julie Koeman, Elizabeth Haak, Karl Dykema, Curt Essenburg, Eric Hudson, David Petillo, Sok Kean Khoo and George F. Vande Woude
In press | Proceedings of the National Academy of Sciences U.S.A.

The role of the unusual threonine string in the conversion of prion protein
Romany Abskharon, Fei Wang, Kayla J. Vander Stel, Kumar Sinniah and Jiyan Ma
2016 | Scientific Reports

Integrated genomic characterization of oesophageal carcinoma
Cancer Genome Atlas Research Network
2017 | Nature

Enhancing the cytotoxic effects of PARP inhibitors with DNA demethylating agents – a potential therapy for cancer
Nidal E. Muvarak, Khadiza Chowdhury, Limin Xia, Carine Robert, Eun Yong Choi, Yi Cai, Marina Bellani, Ying Zou, Zeba N. Singh, Vu H. Duong, Tyler Rutherford, Pratik Nagaria, Søren M. Bentzen, Michael M. Seidman, Maria R. Baer, Rena G. Lapidus, Stephen B. Baylin and Feyruz V. Rassool
2016 | Cancer Cell

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers
Erik S. Linklater, Elizabeth A. Tovar, Curt J. Essenburg, Lisa Turner, Zachary Madaj, Mary E. Winn, Marianne K. Melnik, Hasan Korkaya, Christiane R. Maroun, James G. Christensen, Matthew R. Steensma, Julie L. Boerner and Carrie R. Graveel
2016 | Oncotarget

A gastric glycoform of MUC5AC is a biomarker of mucinous cysts of the pancreas
Jessica Sinha, Zheng Cao, Jianliang Dai, Huiyuan Tang, Katie Partyka, Galen Hostetter, Diane M. Simeone, Ziding Feng, Peter J. Allen, Randall E. Brand and Brian B. Haab
2016 | PLoS One