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Hot Papers

Read the latest research from our laboratories published in scientific journals.

Defining driver DNA methylation changes in human cancer 
Gerd P. Pfeifer 
2018 | International Journal of Molecular Sciences

DNA methylation loss in late-replicating domains is linked to mitotic cell division 
Wanding Zhou, Huy Q. Dinh, Zachary Ramjan, Daniel J. Weisenberger, Charles M. Nicolet, Hui Shen, Peter W. Laird and Benjamin P. Berman 
2018 | Nature Genetics

Genomic status of MET potentiates sensitivity to MET and MEK inhibition in NF1-related peripheral nerve sheath tumors
Jacqueline D. Peacock, Matthew G. Pridgeon, Elizabeth A. Tover, Curt J. Essenburg, Megan J. Bowman, Zachary B. Madaj, Julie Koeman, Elissa A. Boguslawski, Jamie Grit, Rebecca D. Dodd, Vadim Khachaturov, Diana M. Cardona, Mark Chen, David G. Kirsch, Flavio Maina, Rosanna Dono, Mary E. Winn, Carrie R. Graveel and Matthew R. Steensma 
In press | Cancer Research 

Prion infectivity is encoded exclusively within the structure of proteinase K–resistant fragments of synthetically generated recombinant PrPSc
Fei Wang, Xinhe Wang, Romany Abskharon and Jiyan Ma 
2018 | Acta Neuropathologica Communications

The atomic structure of a eukaryotic oligosaccharyltransferase complex 
Lin Bai, Tong Wang, Gongpu Zhao, Amanda Kovach and Huilin Li 
2018 | Nature 

Detecting alpha synuclein seeding activity in formaldehyde-fixed MSA patient tissue by PMCA 
Katelyn Becker, Xinhe Wang, Kayla Vander Stel, Yaping Chu, Jeffrey Kordower and Jiyan Ma 
In press | Molecular Neurobiology 

Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance 
Robert M. Vaughan, Bradley M. Dickson, Evan M. Cornett, Joseph S. Harrison Brian Kuhlman, and Scott B. Rothbart 
In press | Nucleic Acids Research 

Effect of deliberation on the public’s attitudes toward consent policies for biobank research 
Tom Tomlinson, Raymond G. De Vries, H. Myra Kim, Linda Gordon, Kerry A. Ryan, Chris D. Krenz, Scott Jewell and Scott Y.H. Kim 
2018 | European Journal of Human Genetics

Parkinson’s disease genetic risk in a midbrain neuronal cell line 
Steven E. Pierce, Trevor Tyson, Alix Booms, Jordan Prahl and Gerhard A. Coetzee 
2018 | Neurobiology of Disease 

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from TACL consortium 
Weili Sun, Timothy Triche, Jr., Jemily Malvar, Paul Gaynon, Richard Sposto, Xiaojing Yang, Henrique Bittencourt, Andrew E. Place, Yoav Messinger, Chris Fraser, Luciano Dalla-Pozza, Bodour Salhia, Peter Jones, Alan S. Wayne, Lia Gore, Todd M. Cooper and Gangning Liang 
2018 | Blood 

Cytosine modifications exhibit circadian oscillation that are involved in epigenetic diversity and aging 
Gabriel Oh, Sasha Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel E. Groot, Viviane Labrie, Peixin Jia, Edward S. Oh, Richie H. Jeremian, Miki Susic, Tenjin C. Shrestha, Martin R. Ralph, Juozas Gordevičius, Karolis Konvevičius and Art Petronis 
2018 | Nature Communications 

Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cells
Huadie Liu, Jianshuang Li, Di Lu, Jie Li, Minmin Liu, Yuanzheng He, Bart O. Williams, Jiada Li and Tao Yang 
2018 | Scientific Reports

A highly sensitive non-radioactive activity assay for AMP-activated protein kinase (AMPK) 
Yan Yan, Xin Gu, H. Eric Xu and Karsten Melcher 
2018 | Methods and Protocols 

The ring-shaped hexameric helicases that function at DNA replication forks 
Michael E. O’Donnell and Huilin Li 
2018 | Nature Structural & Molecular Biology 

The College of American Pathologists Biorepository Accreditation Program: results from the first 5 years 
Shannon J. McCall, Philip A. Branton, Victoria M. Blanc, Sarah M. Dry, Julie M. Gastier-Forster, James H. Harrison, Scott D. Jewell, Rajesh C. Dash, Rebecca C. Obeng, Joan Rose, Dawna L. Mateski, Albi Liiubinskas, James A. Robb, Nilsa C. Ramirez and Kathi Shea. 
2018 | Biopreservation and Biobanking 

Loss of TGF-β signaling in osteoblasts increases basic-FGF and promotes prostate cancer bone metastasis
Xiangqi Meng, Alexandra Vander Ark, Paul Daft, Erica Woodford, Jie Wang, Zachary Madaj and Xiaohong Li 
In press | Cancer Letters

Desumoylase SENP6 maintains osteochrondroprogenitor homeostasis by suppressing the p53 pathway
Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T.H. Yeh, Bart O. Williams, Ling Zheng, and Tao Yang  
2018 | Nature Communications