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February 2021

Hisao Masai, Ph.D. – VAI Seminar Series

February 17 @ 12:00 pm
Virtual MI United States

Positive and negative regulation of DNA replication through G-quadruplexes G-quadruplexes (G4s) appear in both DNA and RNA, and recent studies implicate these structures in various biological reactions including telomere regulation, epigenome regulation, transcription, translation, splicing, viral maintenance and functions, transpositions, repair and recombination. In this seminar I would like to introduce our recent studies on its roles in regulation of DNA replication. Genome needs to replicate itself once and only once with minimum error in a given cell cycle. This…

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March 2021

David J. Daniels, M.D., Ph.D. – VAI Seminar Series

March 3 @ 12:00 pm
Virtual MI United States

From neurosurgery to histones: Targeting H3K27M tumors David Daniels, M.D., Ph.D., is a pediatric neurosurgeon and medicinal chemist at Mayo Clinic in Rochester MN. He is a clinician-scientist with a research focus in neuro-oncology and has a 50% research appointment.  The majority of his clinical practice centers on treating children with brain tumors.  David’s research interests revolve around the integration of neuro-oncology with neurosurgery. This includes developing new tools to improve surgical resection and decrease surgical morbidity for brain tumor…

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Marnie Blewitt, Ph.D. – VAI Seminar Series

March 24 @ 4:00 pm
Virtual MI United States

Deciphering the molecular mechanism of the epigenetic modifier SMCHD1 in normal development and disease Dr. Blewitt did her Ph.D. with Prof. Emma Whitelaw (University of Sydney), and her postdoctoral studies with Prof. Douglas Hilton (WEHI). In her postdoc, she identified a critical role for the novel protein Smchd1 in X inactivation, and studied the role of polycomb group proteins in hematopoietic stem cell function, earning her the Australian Academy of Sciences Gani medal and the L’Oreal Australia Women in Science…

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April 2021

Thomas Wichmann, M.D. – Jay Van Andel Seminar Series

April 14 @ 12:00 pm
Virtual MI United States

The role of the thalamus in primate Parkinsonism Dr. Wichmann received medical training in Germany, followed by postdoctoral training in pharmacology and electrophysiology at the University of Freiburg (Germany) and Johns Hopkins University (Baltimore, MD). In the early 1990s, he completed residency training in Neurology at Emory University (Atlanta, GA), and has been a professor in the movement disorder division in the Department of Neurology at the same University since then, specializing in research and treatment of Parkinson’s disease and…

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May 2021

Yi Xing, Ph.D. – VAI Seminar Series

May 12 @ 12:00 pm

Title TBD Speaker Information Yi Xing, Ph.D. University of Pennsylvania Time & Location 12:00 pm on Zoom VAI Host: Hui Shen, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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Prof. Muzlifah Haniffa, FMedSci – VAI Seminar Series

May 19 @ 12:00 pm
Virtual MI United States

Decoding the developing human immune system Muzlifah has combined single cell genomics and immunology to decode the developing human immune system. Muzlifah Haniffa is a Wellcome Trust Senior Research Fellow, Lister Institute Research Fellow and Consultant Dermatologist based in Newcastle University. She graduated from medical school in Cardiff, trained as a junior doctor in Cambridge and received her dermatology specialist training in Newcastle. She was awarded an Action Medical Research Training Fellowship and a Wellcome Trust Clinical Intermediate Fellowship. Muzlifah…

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Olivia S. Rissland, Ph.D. – VAI Seminar Series

May 26 @ 12:00 pm

Control of RNA Binding Proteins During Early Embryogenesis The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome, we previously found that three maternally deposited Drosophila RNA binding proteins (ME31B, Trailer Hitch , and Cup) are also cleared during the MZT by unknown mechanisms. Here, we show that these proteins are degraded by the ubiquitin-proteasome system.…

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June 2021

Warren Hirst, Ph.D. – VAI Seminar Series

June 2 @ 12:00 pm

Developing novel Parkinson’s disease therapeutics: Opportunities and challenges Warren Hirst is Senior Director and head of the movement disorders preclinical research efforts in Biogen’s Research organization, a role he has led since joining them in 2016. Warren is responsible for developing and driving a diverse preclinical portfolio of programs, using multiple modalities, from antibodies and antisense oligonucleotides, in collaboration in Ionis, to gene therapy and small molecules, targeting mechanisms strongly supported by human genetics and pathology, to deliver novel disease-modifying…

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Thomas Montine, M.D., Ph.D. – Jay Van Andel Seminar Series

June 30 @ 12:00 pm
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States

“Synaptopathology in Alzheimer’s and Parkinson’s diseases” Dr. Montine received his education at Columbia University (BA in Chemistry), the University of Rochester (PhD in Pharmacology), and McGill University (MD and CM). His postgraduate medical training was at Duke University, and he was junior faculty at Vanderbilt University where he was awarded the Thorne Professorship in Pathology. In 2002, Dr. Montine was appointed as the Alvord Endowed Professor in Neuropathology and Director of the Division of Neuropathology at the University of Washington.…

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July 2021

Origins of Cancer

July 22 - July 23
Virtual MI United States

Origins of Cancer is a scientific symposium that brings together students, scientists and medical professionals to discuss the latest breakthroughs in cancer research. The 2021 meeting will delve into the emerging field of cancer neuroscience. Speakers will discuss the unique genetics and epigenetics of brain tumors, neural signaling mechanisms that influence tumor initiation and progression, the cellular pathways driving epidemiologic links between cancer and neurodegenerative disease, the neurotoxicity of cancer treatments and more.

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