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September 2020

Valina L. Dawson, Ph.D. – Jay Van Andel Seminar Series

September 9, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Decoding Parkinson’s disease: New therapeutic opportunities Parkinson's disease (PD) is the second most common neurodegenerative disease. There is currently no therapy that can slow or halt the progression of the disease. Individuals with PD have both motor and non-motor symptoms. While 10-15% of PD is due to genetic mutations the majority of PD is sporadic. It is thought that the neurodegenerative process of PD in both familial and sporadic PD is driven by pathological alpha-synuclein, a presynaptic neuronal protein that…

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Grand Challenges in Parkinson’s Disease (Virtual)

September 23, 2020 - September 25, 2020
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Grand Challenges in Parkinson’s Disease brings together hundreds of scientists, clinicians and people with Parkinson’s to explore the latest Parkinson’s disease research. The theme for 2020 is When and How Does Parkinson’s Start?, which will focus on the origins and development of Parkinson’s, from potential triggers through the early symptoms and stages of the disease. Van Andel Institute and The Cure Parkinson’s Trust are thrilled to once again host Rallying to the Challenge, a meeting designed for and by people with Parkinson’s,…

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October 2020

Karen Vasquez, Ph.D. – VAI Seminar Series

October 7, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Novel mechanisms of genetic instability in cancer Repetitive sequences have the capacity to adopt alternative DNA structures (e.g. H-DNA and Z-DNA) and stimulate genetic instability in the absence of exogenous DNA damage. However, the biological significance and the mechanisms of this DNA-structure-induced genetic instability are unknown. Here, we report that H-DNA- and Z-DNA-forming sequences are enriched at translocation breakpoints in human cancer genomes, implicating them in cancer etiology. We found that H-DNA-induced mutations were suppressed in human cells deficient in…

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Lewis Cantley, Ph.D. – VAI Seminar Series

October 14, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

PI 3-kinase and cancer metabolism Lewis Cantley, Ph.D., has made significant advances in cancer research stemming from his discovery of the signaling pathway phosphoinositide 3-kinase (PI3K) in 1984. The author of more than 400 original papers, 50 book chapters and review articles, Dr. Cantley is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Science, the Institute of Medicine of the National Academies, and the European life sciences academy EMBO. He…

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Susanna Greer, Ph.D. – VAI Seminar Series

October 28, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Title TBD Speaker Information Susanna Greer, Ph.D. Director, Clinical Cancer Research, Nutrition and Immunology American Cancer Society Time & Location 12:00 pm on Zoom VAI Host: Graduate Student Association, Katie Hollis Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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December 2020

Sharona E. Gordon, Ph.D. – VAI Seminar Series

December 2, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Title TBD Speaker Information Sharona E. Gordon, Ph.D. Professor and Associate Dean for Research and Graduate Education University of Washington School of Medicine Time & Location 12:00 pm on Zoom VAI Host: Juan Du, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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February 2021

Hisao Masai, Ph.D. – VAI Seminar Series

February 17 @ 12:00 pm
Virtual MI United States

Positive and negative regulation of DNA replication through G-quadruplexes G-quadruplexes (G4s) appear in both DNA and RNA, and recent studies implicate these structures in various biological reactions including telomere regulation, epigenome regulation, transcription, translation, splicing, viral maintenance and functions, transpositions, repair and recombination. In this seminar I would like to introduce our recent studies on its roles in regulation of DNA replication. Genome needs to replicate itself once and only once with minimum error in a given cell cycle. This…

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March 2021

David J. Daniels, M.D., Ph.D. – VAI Seminar Series

March 3 @ 12:00 pm
Virtual MI United States

From neurosurgery to histones: Targeting H3K27M tumors David Daniels, M.D., Ph.D., is a pediatric neurosurgeon and medicinal chemist at Mayo Clinic in Rochester MN. He is a clinician-scientist with a research focus in neuro-oncology and has a 50% research appointment.  The majority of his clinical practice centers on treating children with brain tumors.  David’s research interests revolve around the integration of neuro-oncology with neurosurgery. This includes developing new tools to improve surgical resection and decrease surgical morbidity for brain tumor…

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Marnie Blewitt, Ph.D. – VAI Seminar Series

March 24 @ 4:00 pm
Virtual MI United States

Deciphering the molecular mechanism of the epigenetic modifier SMCHD1 in normal development and disease Dr. Blewitt did her Ph.D. with Prof. Emma Whitelaw (University of Sydney), and her postdoctoral studies with Prof. Douglas Hilton (WEHI). In her postdoc, she identified a critical role for the novel protein Smchd1 in X inactivation, and studied the role of polycomb group proteins in hematopoietic stem cell function, earning her the Australian Academy of Sciences Gani medal and the L’Oreal Australia Women in Science…

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April 2021

Thomas Wichmann, M.D. – Jay Van Andel Seminar Series

April 14 @ 12:00 pm
Virtual MI United States

The role of the thalamus in primate Parkinsonism Dr. Wichmann received medical training in Germany, followed by postdoctoral training in pharmacology and electrophysiology at the University of Freiburg (Germany) and Johns Hopkins University (Baltimore, MD). In the early 1990s, he completed residency training in Neurology at Emory University (Atlanta, GA), and has been a professor in the movement disorder division in the Department of Neurology at the same University since then, specializing in research and treatment of Parkinson’s disease and…

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