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February 2020

Janelle Ayres, Ph.D. – VAI Seminar Series

February 12, 2020 @ 12:00 pm - 1:00 pm
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Host-microbe interactions: targeting co-evolution to treat disease Speaker Information Janelle Ayres, Ph.D. Professor Molecular and Systems Physiology Lab Gene Expression Laboratory Nomis Center for Immunobiology and Microbial Pathogenesis The Salk Institute for Biological Studies Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Postdoctoral Association, Emmanuel Quansah, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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Jerry Workman, Ph.D. – VAI Seminar Series

February 26, 2020 @ 12:00 pm - 1:00 pm
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Nutritional stress signaling through chromatin Our laboratory has extensive experience in the purification and analysis of protein complexes that modify chromatin for gene expression. This includes both affinity purification techniques and conventional chromatography. Examples of complexes first purified in this laboratory include the SAGA complex from yeast the Tip60 complex from Drosophila and the Sin3 complex from mammalian cells. We have extensively analyzed the mammalian Sin3 deacetylase complexes in collaboration with the Washburn laboratory. We have collaborated extensively with the…

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July 2020

Origins of Cancer

July 24, 2020 @ 8:00 am
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Origins of Cancer is a one-day symposium that brings together students, scientists and medical professionals to discuss the latest breakthroughs in cancer research. This year’s meeting will highlight the tumor macroenvironment, which comprises near and far cells, tissues and systems that interact with primary cancer cells to promote tumor survival. Invited speakers also will discuss novel and integrative treatment approaches that target this larger interactome to outsmart cancer cells.

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September 2020

Elaine R. Mardis, Ph.D. – VAI Seminar Series

September 2, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Implementing genomics-guided precision pediatric cancer medicine Elaine Mardis, Ph.D. is Co-Executive Director of the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital and holds the Rasmussen Nationwide Foundation Endowed Chair of Genomic Medicine. She also is Professor of Pediatrics at The Ohio State University College of Medicine. Educated at the University of Oklahoma with a B.S. in Zoology and a Ph.D. in Chemistry and Biochemistry, Dr. Mardis did postgraduate work in industry at BioRad Laboratories. She…

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Valina L. Dawson, Ph.D. – Jay Van Andel Seminar Series

September 9, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Decoding Parkinson’s disease: New therapeutic opportunities Parkinson's disease (PD) is the second most common neurodegenerative disease. There is currently no therapy that can slow or halt the progression of the disease. Individuals with PD have both motor and non-motor symptoms. While 10-15% of PD is due to genetic mutations the majority of PD is sporadic. It is thought that the neurodegenerative process of PD in both familial and sporadic PD is driven by pathological alpha-synuclein, a presynaptic neuronal protein that…

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Grand Challenges in Parkinson’s Disease (Virtual)

September 23, 2020 - September 25, 2020
Van Andel Institute, 333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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Grand Challenges in Parkinson’s Disease brings together hundreds of scientists, clinicians and people with Parkinson’s to explore the latest Parkinson’s disease research. The theme for 2020 is When and How Does Parkinson’s Start?, which will focus on the origins and development of Parkinson’s, from potential triggers through the early symptoms and stages of the disease. Van Andel Institute and The Cure Parkinson’s Trust are thrilled to once again host Rallying to the Challenge, a meeting designed for and by people with Parkinson’s,…

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October 2020

Karen Vasquez, Ph.D. – VAI Seminar Series

October 7, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Novel mechanisms of genetic instability in cancer Repetitive sequences have the capacity to adopt alternative DNA structures (e.g. H-DNA and Z-DNA) and stimulate genetic instability in the absence of exogenous DNA damage. However, the biological significance and the mechanisms of this DNA-structure-induced genetic instability are unknown. Here, we report that H-DNA- and Z-DNA-forming sequences are enriched at translocation breakpoints in human cancer genomes, implicating them in cancer etiology. We found that H-DNA-induced mutations were suppressed in human cells deficient in…

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Lewis Cantley, Ph.D. – VAI Seminar Series

October 14, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

PI 3-kinase and cancer metabolism Lewis Cantley, Ph.D., has made significant advances in cancer research stemming from his discovery of the signaling pathway phosphoinositide 3-kinase (PI3K) in 1984. The author of more than 400 original papers, 50 book chapters and review articles, Dr. Cantley is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Science, the Institute of Medicine of the National Academies, and the European life sciences academy EMBO. He…

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Susanna Greer, Ph.D. – VAI Seminar Series

October 28, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Title TBD Speaker Information Susanna Greer, Ph.D. Director, Clinical Cancer Research, Nutrition and Immunology American Cancer Society Time & Location 12:00 pm on Zoom VAI Host: Graduate Student Association, Katie Hollis Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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December 2020

Sharona E. Gordon, Ph.D. – VAI Seminar Series

December 2, 2020 @ 12:00 pm - 1:00 pm
Virtual MI United States

Title TBD Speaker Information Sharona E. Gordon, Ph.D. Professor and Associate Dean for Research and Graduate Education University of Washington School of Medicine Time & Location 12:00 pm on Zoom VAI Host: Juan Du, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

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