TRIM24: an oncogenic histone reader in breast cancer Epigenetic factors are frequent targets of aberrant regulation, amplification or mutation in all human cancers. The interest in epigenetics for therapeutic development lies in the potential reversibility of epigenetic changes. Our laboratory focuses on Tripartite Motif Protein 24 (TRIM24), a multi-functional protein that i) negatively regulates p53 as an E3-ligase, ii) is a nuclear receptor co-regulator and iii) a PHD/bromodomain histone reader that recognizes a unique signature of histone PTMs (H3K4me0;H3K23ac). Recently,…

From Neurosurgery to Histones: Targeting H3K27M tumors David Daniels MD PhD is a pediatric neurosurgeon and medicinal chemist at Mayo Clinic in Rochester MN. He is a clinician-scientist with a research focus in neuro-oncology and has a 50% research appointment.  The majority of his clinical practice centers on treating children with brain tumors.  David’s research interests revolve around the integration of neuro-oncology with neurosurgery. This includes developing new tools to improve surgical resection and decrease surgical morbidity for brain tumor…

Epigenetics: A gatekeeper to DNA amplification and Drug response My laboratory studies how the chromatin microenvironment regulates gene expression while maintaining a stable genome.  We have initiated these types of studies by focusing on a specific class of chromatin regulators, JmjC-containing histone demethylases.  Since their discovery, my laboratory has been screening both solid and hematopoietic cancer for genomic anomalies in this class of enzymes.  We have uncovered the first enzyme (KDM4A- histone tri-demethylase) responsible for generating site-specific DNA copy gain…

Title TBD Speaker Information Regis O’Keefe, M.D., Ph.D. Chair, Department of Orthopaedic Surgery Fred C. Reynolds Professor of Orthopaedic Surgery Washington University School of Medicine Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Tao Yang, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

Title TBD Speaker Information Gregory Longmore, M.D. Professor, Departments of Medicine and of Cell Biology and Physiology Washington University in St. Louis Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Xiaohong Li, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.

Title TBD Speaker Information Yi Xing, Ph.D. Francis West Lewis Chair Director, Center for Computational and Genomic Medicine The Children's Hospital of Philadelphia Professor of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania Time & Location 12:00 pm at Van Andel Institute Conference Room 3104/3105 VARI Host: Hui Shen, Ph.D. Questions? For questions, please contact Kim Cousineau at 616.234.5684.