Wentian Yang, M.D., Ph.D. – VAI Seminar Series

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Wentian Yang, M.D., Ph.D. – VAI Seminar Series

December 1, 2021 @ 12:00 pm

The roles of PTPN11 in skeletal development and diseases

Dr. Yang received his M.D. from Lanzhou University School of Medicine and his Ph.D. in Molecular Biology from Sichuan University in China. After completing a postdoctoral fellowship with Dr. Benjamin Neel at Harvard University, he joined the Department of Orthopaedics at Brown University as a faculty member in 2007. Dr. Yang has received several honors and awards and currently serves on several professional research and education committees. Dr. Yang’s research focuses on elucidating the role of protein tyrosine phosphatases in skeletal development and diseases. His research bridges discoveries of fundamental mechanisms with a better molecular and cellular understanding of human diseases in bone and cartilage. Over the past decade, Dr. Yang’s laboratory has been investigating how bone and cartilage development and homeostasis are regulated by the Src homology 2-domain containing tyrosine phosphatase SHP2. His lab discovered a novel population of cathepsin K (Ctsk)-expressing skeletal stem cells (CSC) and found that SHP2 deficiency in CSC causes human cartilage tumor syndrome metachondromatosis (Nature, 2013). His lab also reported SHP2’s requirement in osteoclastogenesis by promoting the fusion of preosteoclasts (FASEBJ, 2015, 2018) and in osteoblast development and functional maturation through modifying SOX9 and OSTERIX transcriptional activity (Bone Research 2018, 2021). Early in his career, Dr. Yang made contributions to the discoveries of SHP2 as a key regulator of the Src family kinase activation (Molecular Cell, 2004), embryonic and tissue stem cell survival (Developmental Cell, 2006), normal hematopoiesis and hematopoietic malignancy (Blood, 2009 & 2011; Leukemia 2018), and the pathogenesis of Noonan syndrome (Nature Medicine, 2006).

Speaker Information

Wentian Yang, M.D., Ph.D.
Associate Professor of Orthopedics and Associate Professor of Medicine
Rhode Island Hospital/Brown University Alpert Medical School

Time & Location

12:00 pm on Zoom, please contact Courtney Zirkle at 616.234.5821 to receive the link for the seminar.

VAI Host: Tao Yang, Ph.D.


For questions, please contact Courtney Zirkle at 616.234.5821.


December 1, 2021
12:00 pm
Event Category:


Van Andel Institute
333 Bostwick Ave. NE
Grand Rapids, MI 49503 United States
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