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Transcriptional regulation by gene- and cell-specific DNA-binding factors underlies key events in development, cell differentiation and transformation. However, their effects on specific genes depend upon complex arrays of cofactors that include both chromatin modifying factors (e.g., histone acetyl-transferases and methyl-transferases) and other factors (e.g., Mediator and TAFs) that facilitate more direct communication between enhancer-bound regulatory factors and the general transcription machinery. Emphasizing biochemical studies with cell-free systems reconstituted with recombinant chromatin templates and purified transcription factors, as well as cell-based and genetic analyses, the cooperative functions and mechanism of action of various co-activators will be discussed in relation to gene regulation by selected activators (p53, nuclear receptors, B cell factors, or leukemic fusion proteins).
Robert Roeder, Ph.D.
Arnold and Mabel Beckman Professor
The Rockefeller University
12:00 pm at Van Andel Institute
Conference Room 3104/3105
For questions, please contact Kim Cousineau at 616.234.5684.