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The mammalian genome produces many thousands of lncRNAs–transcripts >200 nucleotides long that do not code for protein, and it is now clear that certain lncRNAs have critical biological functions and roles in human neurological disease. Both lncRNA knockdown and more recent conditional genetic knockout methods indicate that one particular lncRNA called Pnky has key roles in the regulation of neurogenesis from neural stem cells in the embryonic and postnatal brain. Single cell sequencing of neural precursors from the developing human brain indicate that many lncRNAs are abundantly expressed in specific cell types including radial glia. In a more recent large-scale CRISPR interference (CRISPRi) based screen, we have identified several hundred lncRNAs that have essential roles in cell proliferation including that of glioblastoma multiforme (GBM) Surprisingly, lncRNAs were found to have exquisitely cell-type specific function. We are continuing to determine the function of many of these lncRNAs and the molecular mechanisms by which they regulate neural development and brain tumors.
Daniel Lim, M.D., Ph.D.
School of Medicine
University of California, San Francisco
12:00 pm at Van Andel Institute
Conference Room 3104/3105
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